RESUMO
Lung cancer is the malignant tumor with the highest incidence and mortality among the Chinese.Tumor node metastasis(TNM)staging established by the American Joint Committee on Cancer(AJCC)and International Union Against Cancer(UICC)is a commonly used criterion,but it still has limitations in judging the prognosis of non-small cell lung cancer(NSCLC)patients.With the advantages of real-time and convenient sampling,the immune score based on peripheral blood biomarkers have the ability to predict prognosis and efficacy of NSCLC patients,which have been developed and validated in clinical studies.However,clinical impleruentation of peripheral immune scores is still not widely in NSCLC patients.Therefore,this study introduces and evaluates the 6 peripheral immune scores and reviews the reseach progress of them in the treatment of NSCLC.
RESUMO
@#Objective To investigate the correlation and diagnostic value of miR-96 and serum IGF-1 in patients with post-stroke cognitive dysfunction (PSCI).Methods 178 patients with ischemic stroke in recovery stage were recruited and divided into PSCI group (n=61) and non-PSCI group (n=117),expression levels of miR-96 and serum IGF-1 were compared.Patients were further divided into high miR-96 group and low miR-96 group according to the median levels,MOCA scores was compared.Auxiliary diagnostic value of miR-96,serum IGF-1 levels in PSCI were analyzed.Results Expression level of miR-96 of PSCI group was higher,serum IGF-1 was lower than that of non-PSCI group (P<0.05).Pearson test showed that expression level of miR-96 of PSCI patients was negatively correlated with the level of serum IGF-1 (P<0.05).MOCA score in high miR-96 group and low IGF-1 group were lower than those in low miR-96 group and high IGF-1 group (P<0.05).ROC curve showed mir-96 had good diagnostic value for PSCI.Conclusion High expression of miR-96 in PSCI patients can downregulate the level of IGF-1,and early determination of the level of miR-96 has auxiliary diagnostic value for PSCI.