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Objective: To observe the clinical efficacy of combining auricular point sticking and a healthy diet to treat simple obesity in children aged 6-9 years old.Methods: A total of 190 eligible obese kids were divided into an observation group and a control group using the random number table method, with 95 cases in each group. The observation group was intervened by auricular point sticking plus guide on a healthy diet, while the control group was only provided with the guide on a healthy diet. The therapeutic efficacy was observed after intervention for three consecutive months, as well as the changes in body mass (BM), body mass index (BMI), waist circumference (WC), hip circumference (HC), and subcutaneous fat thickness. Results: After the 3-month intervention, the total effective rate was 91.6％ in the observation group, versus 74.7％ in the control group, and the between-group difference was statistically significant (P<0.01); in both groups, the BM, BMI, WC, HC, and subcutaneous fat thickness all decreased significantly (P<0.05), and were lower in the observation group than in the control group, showing statistical significance (P<0.05). Conclusion: Auricular point sticking plus a healthy diet is safe and effective in treating simple obesity in children, producing more significant efficacy than healthy diet intervention alone.
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Aim To observe the protective effects of total flavonoids from Anchusa italica Retz, and four compounds on hypoxia/reoxygenation (H / R) injury in myocardial cells and to explore the mechanisms. Methods Primary neonatal rat cardiomyocytes were isolated, cultured and were randomly divided into different groups. The H / R model of cultured neonatal rat cardiomyocytes was developed. The related indexes were determined after administration. Results Compared with model group, the total flavonoids and the four compounds could increase the survival rate of H / R cardiomyocytes (P < 0. 01), reduce the leakage of LDH (P < 0 . 0 1), reduce the content of M DA (P < 0 . 0 1), significantly increase the activity of SOD (P <0. 01), significantly decrease the early apoptosis index and increase the mitochondrial membrane potential (P < 0. 01) . The activation of key proteins in NF-KB signaling pathway was inhibited, the proportion of Bax / Bc l - 2, beclin-1 and p62 significantly decreased (P < 0. 01), and the expression of apoptosis related proteins NLRP3, IL - lß and GSDMD significantly decreased (P <0. 0 1) . Conclusions The total flavonoids and four compounds can alleviate the damage of H/R on cardiomyocytes. The mechanism is related to the inhibition of the activation of NF-KB signaling pathway and the excessive autophagy of cardiomyocytes, alleviation of the scorch death of cardiomyocytes, and reduction of the apoptosis of cardiomyocytes.
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Objective To observe changes in the infrared thermogram of Yangming meridian acupoints in patients with idiopathic facial paralysis in acute stage. Method High-performance uncooled infrared focal plane array (M7800 Thermal Imager, LumaSense, USA) was used to detect the infrared thermogram of Yangming meridian acupoints[Kouheliao (LI19), Yingxiang (LI20), Hegu (LI4), Shangyang (LI1), Chengqi (ST1), Sibai (ST2), Juliao (ST3), Dicang (ST4), Daying (ST5), Jiache (ST6), Xiaguan (ST7), Tianshu (ST25), and Zusanli (ST36) ]of 80 patients with idiopathic facial paralysis in acute stage and 75 healthy subjects. The temperature data of the meridian acupoints obtained from the analysis software were statistically processed. Result Compared with the healthy subjects, the temperature differencesΔT of the Hand Yangming Meridian acupoints including Kouheliao, Yingxiang and Hegu, and Foot Yangming Meridian acupoints including Chengqi, Sibai, Juliao, Dicang, Daying, Jiache and Xiaguan were more significant in the patients with idiopathic facial paralysis in acute stage, and the differences were statistically significant (P<0.05); the temperature differences ΔT of the Hand Yangming Meridian acupoint Shangyang, and the Foot Yangming Meridian acupoints including Tianshu and Zusanli in the facial paralysis patients showed insignificant differences compared with those in the healthy subjects (P>0.05). Conclusion There are changes in the infrared thermogram at Yangming meridian acupoints located on face (Kouheliao, Yingxiang, Shangyang, Chengqi, Sibai, Juliao, Dicang, Daying, Jiache and Xiaguan) and the distant acupoint Hegu in idiopathic facial paralysis patients in acute stage, while Shangyang, Tianshu and Zusanli do not present the above phenomenon, indicating the specificity of acupoint effect from the perspective of infrared.