Tumor immune microenvironment-modulated nanostrategy for the treatment of lung cancer metastasis / 中华医学杂志(英文版)

As one of the most malignant tumors worldwide, lung cancer, fueled by metastasis, has shown rising mortality rates. However, effective clinical strategies aimed at preventing metastasis are lacking owing to its dynamic multi-step, complicated, and progressive nature. Immunotherapy has shown promise in treating cancer metastasis by reversing the immunosuppressive network of the tumor microenvironment. However, drug resistance inevitably develops due to inadequate delivery of immunostimulants and an uncontrolled immune response. Consequently, adverse effects occur, such as autoimmunity, from the non-specific immune activation and non-specific inflammation in off-target organs. Nanocarriers that improve drug solubility, permeability, stability, bioavailability, as well as sustained, controlled, and targeted delivery can effectively overcome drug resistance and enhance the therapeutic effect while reducing adverse effects. In particular, nanomedicine-based immunotherapy can be utilized to target tumor metastasis, presenting a promising therapeutic strategy for lung cancer. Nanotechnology strategies that boost the immunotherapy effect are classified based on the metastatic cascade related to the tumor immune microenvironment; the breaking away of primary tumors, circulating tumor cell dissemination, and premetastatic niche formation cause distant secondary site colonization. In this review, we focus on the opportunities and challenges of integrating immunotherapy with nanoparticle formulation to establish nanotechnology-based immunotherapy by modulating the tumor microenvironment for preclinical and clinical applications in the management of patients with metastatic lung cancer. We also discuss prospects for the emerging field and the clinical translation potential of these techniques.

The influence of different processing methods on chemical ingredient of Flos Lonicerae / 中国基层医药

Objective To investigate the influence of different processing methods on chemical ingredient of Flos Lonicerae.Methods Preparaed the fried yellow products and baked products of Flos Lonicerae,chlorogenic acid was used as indexity ingredients,using high performance liquid chromatography with diode array detection method,compared and analyzed the ingredient through the fingerprint chromatogram.Results The no.2 peak on the fingerprint chromatogram of fried yellow products and baked products was chlorogenic acid; The area of 1 1 chromatogram peak on the fingerprint chromatogram of fried yellow products was greater than the raw product,this accounted for most of the dissolution rate of the chemical ingredient increased after Flos Lonicerae fried yellow; The areas of 1,3,6,8number chromatogram peak(262 320,337 986,342 635,190 073) on the fingerprint chromatogram of baked products were greater than the raw product(108 872,267 823,308 942,143 829),the rest was smaller than the raw product,thel 1 number chromatogram peak disappeared,this accounted for most of the dissolution rate of the chemical ingredient was reduced,a few chemical ingredient increased,one chemical ingredient disappeared after baked.Conclusion The different processing methods of Flos Lonicerae had great influence on the chemical ingredient.