A Clinical Study of 16 Cases of Uterine Sarcomas / 대한산부인과학회잡지

Sarcoma of the uterus is very rare malignant tumor arising from the muscle or connective tissue, and there are only a few cases reported in Korea. We have experienced 16 cases of uterine sarcomas for 10 years from 1986 to 1995. The results are as follows: 1. The incidence of uterine sarcomas in uterine leiomyomas was estimated to 0.69%. 2. The pathologic types were 5 cases(31.3%) of leiomyosarcoma, 3 cases(18.8%) of endometrial stromal sarcoma, 6 cases(37.5%) of malignant mixed Mllerian tumor 2 cases(12.5%) of rhabdomyosarcoma in order. 3. The mean age was 46.4 years. 4. Seven(58.7%) were stage I, 2(16.7%) were stage III, and 3(25.6%) were stage IV. 4. The chief complaints on admission were abdominal mass(50%), abnormal bleeding(25%), and pelvic or abdominal pain(25%). 5. The estimated median survival was 43 months, and there was no correlation between survival and number of mitotic figure per 10 high power fields, stages, or radiation therapy.

A Case of Absence of One Tube and a Corresponding Ovary / 대한산부인과학회잡지

Absence of one tube and a corresponding ovary is very rare anomaly.We reported a case of absence of one tube and a corresponding ovary and reviewthe literature briefly.

Diagnostic Conization of the Cerivx / 대한부인종양콜포스코피학회잡지

To evaluate the effectiveness of conization in the diagnosis of cervical cancer, the histopathologic finding of 464 consecutive cases were analized with respect to the cytology, punch biopsy and hysterectomy. Cold knife conization was performed under direct visualization(naked eye conization) from January, 1987 to Octorber 1994 at department of Obstetrics and Gynecology, Kosin Medical Center. The results were summerized as follows : 1. The rate of agreement and underdiagnosis of between pap smear and naked eye conization were 43.7% and 47%. 2. The rate of agreement and underdiagnosis of between punch biopsy and naked eye conization were 64.5% and 21.8% 3. Subsequent hysterectomy was done on the 382 case and their incidence of residual disease rate was 44.2%(169 cases). Their incidence of residual lesion was increased with severity of the carcinomatous change. 4. The rate of complication undergoing conization was 8.4%(39 cases).

10 Year's Expreience on Gestational Trophoblastic Disease / 대한부인종양콜포스코피학회잡지

For the clinical analysis and evaluation on the patients with gestational trophoblastic disease(GTD), a study was done retrospectively on 114 patients with GTD(60 in Hydatidiform mole, 10 in invasive mole, 44 in choriocarcinoma) treated from Jan. 1, 1985 to Dec. 31, 1994 at the Department of Obstetrics and Gynecology, Kosin Medical College, Pusan, Korea. We obtained the following results ; The incidence of GTD was 1 per 73 deliveries in H. mole, 1 per 437 deliveries in invasive mole, and 1 per 99 deliveries in choriocarcinoma. The most prevalent age was 21-40 groups. Abnormal vaginal bleeding was a main symptom and sign. 30.6% of H. mole was managed by dilatation and curettage. 90.0% of invasive mole and 51.4% of choriocarcinoma were managed by surgical treatment and chemotherapy. The overall remissinon rate of choriocarcinoma was 71.4%(100.0% in stage I, 66.7% in stage II, 54.5% in stage III, 50.0% in stage IV).

Follow up Study of Second Look Laparotomy in Ovarian Cancer patients / 대한부인종양콜포스코피학회잡지

A study was to evaluate the efficacy and clinical utility of second look operation in the managements of malignant ovarian tumor at the Department of Obstetrics and Gynecology, Kosin medical colleage from January 1986 to September 1993. Of 220 patients diagnosed as ovarian cancer, 48 patients who had underwent primariy laparotomy were performed second look operation. Thirty-seven patients were found to have no evidence of disease. The result revealed that negative second look operation rate was noted 96.3% at stage I, 66.6% at stage II, 50.0% at stage III, and 42.9% at stage IV and total negative second look operation rate was 77.1%. The 2 year survival rate for stage I, II, III, IV were 85.2%, 66.6%, 50.0% and 42.9% respectively. The survival rate of negative second look operation was 86.5%, that of positive second look operation was 18.1%. In conclusion, second look operation in early stage ovarian cancer need to be justified.

The Clinical Effect of Recombinant Human Granulocyte-Colony Stimulating Factor to the Leukopenia During Chemotherapy in the Patients with Gynecologic Malignancies / 대한부인종양콜포스코피학회잡지

An increase in the dose of chemotherapy enhances the response of many experimental and clinical cancers, but the extent of chemotherapy dose escalation and repeated use is often limited by myelosuppression. The side effects of chemotherapy including bleeding and infection due to myelosuppression have resulted in delayed therapy and a reduction in the therapeutic dose, therefore it is necessary to overcome myelosuppression especially leukopenia in patients with gynecologic malignancies who recieved chemotherapy. This study is undertaken to investigate the clinical effects of rhG-CSF(recombinant human Granulocyte-colony stimulating factor) in 29 patients with gynecologic malignancy who recieved chemotherapy. It was given at a dose of 100 microgram bid/day subcutaneously until significantly increase of leukocyte count in leukopenic patient. The results showed, the rhG-CSF has significantly increased the number and function of leukocyte. The use of rhG-CSF was effective and useful to treat chemotherapy induced leukopenia and to accelerate the recovery from this complications.