Expression and significance of TRAIL protein and mRNA in hemangioma / 中华整形外科杂志

<p><b>OBJECTIVE</b>To detect the expression of TRAIL protein and mRNA in hemangiomas and vascular malformations.</p><p><b>METHODS</b>Sections of 33 proliferative hemangiomas,28 involuting hemangiomas and 29 vascular malformations were immunostained for TRAIL protein, TRAIL mRNA was examined by in situ hybridization in these tissue.</p><p><b>RESULTS</b>The TRAIL protein positive rates in proliferative hemangiomas, involuting hemangiomas, vascular malformations and normal skins were respectively 45.45% (15/33), 78.57% (22/28), 0% and 0%. There were significant differences among the four pathologies (P < 0.01). The difference between proliferative hemangiomas and involuting hemangiomas was also significant (P < 0.01). The TRAIL mRNA positive rates were 66.67% (11/33), 89.29 (25/28), 0% and 0% respectively. There were also significant differences among the four pathologies (P < 0.01). The difference between proliferative hemangiomas and involuting hemangiomas was also significant (P < 0.01).</p><p><b>CONCLUSIONS</b>TRAIL could induce endothelial apoptosis and cause regression of hemangiomas.</p>

Clinical treatment of venous malformations with retained copper needles / 中华整形外科杂志

<p><b>UNLABELLED</b>OBJECTIVE; To evaluate a technique with retained copper needles for the treatment of venous malformations.</p><p><b>METHODS</b>With 78 venous malformation cases, there were three methods were applied for the treatment respectively, including copper needles in the lesion only, vascular ligation with the copper needles in the lesion, and electrical puncture with the copper needles in the lesion.</p><p><b>RESULTS</b>There were totally 96% effective rate achieved in this clinical data.</p><p><b>CONCLUSIONS</b>The retained copper needles technique may be a simple and effective method for the treatment of venous, malformations resulting in vessel denaturation, fibrosis and disappearance of structure.</p>