Rhabdomyolysis after antipsychotic use: case reports and literature review / 中国药学杂志

OBJECTIVE: Antipsychotic drugs are being widely used for psychiatric disorders, including schizophrenia, bipolar disorders, attention-deficit, autism, depression. Rhabdomyolysis is a rare but potentially serious adverse drug reaction to antipsychotic medicines. To evaluate rhabdomyolysis association with a range of antipsychotic medicines. METHODS: Key terms like’rhabdomyolysis'‘ RM'and’antipsychotic'were used for systematic literature research in Wanfang database, CNKI, Pubmed and Embase respectively. Data collection time ranged from 1980. 1.1 to 2019. 4.1. RESULTS: All the 29 reported cases were absence of NMS. The suspected antipsychotic medicines for these 29 cases were olanzapine (n = 7), quetiapine (n = 6), risperidone (n = 4), haloperidol (n = 3), aripiprazole (n = 2), clozapine (n = 1), mitazapine (n = 3), levomepromazine (n = 1), loxapine(n = 2). Twenty-four (83%) patients were taking two or more medicines. Symptoms of rhabdomyolysis includes muscle pain, weakness in mobility, changes in urine color. Not all patients showed such symptoms. Six cases developed AKI. There is no relationship between the onset of rhabdomyolysis and antipsychotic medicines dosages. CONCLUSION: Antipsychotic drugs use is associated with an increased risk of rhabdomyolysis. It seems more common in those taking polypharmacy. Patients and caregivers should pay attention to the symptoms of muscle pain, weakness in mobility, abdominal pain, changes in urine color, especially dosage increment or starting a new medication.

Population pharmacokinetics of norvancomycin / 中国感染与化疗杂志

85 mL/min),CL=6.0?(WT/60)~(0.52).④The increased volume of peripheral distribution (V_2) was observed when norvancomycin was co-administered with diuretics;④Reduced drug clearance,prolonged t_(1/2),and increased values of AUC_(24) were found in elderly patients.Conclusions Renal function impairment and age have significant impact on PK parameters of norvancomycin.Dosing regimens of norvancomycin were finally established for different patients on the basis of important PPK parameters generated from different groups of patients.

Study on bioequivalence of domestic bambuterol capsules and imported tablets by high performance capillary zone electrophoresis / 药学学报

<p><b>AIM</b>To study bioequivalences of bambuterol and its metabolites terbutaline in 20 healthy male volunteers.</p><p><b>METHODS</b>A single oral dose of domestic bambuterol capsule or imported bambuterol tablet was given according to a randomized 2-way cross-over design. The plasma bambuterol and terbutaline concentrations were determined by high performance capillary zone electrophoresis (HPCZE).</p><p><b>RESULTS</b>The pharmacokinetic parameters of the capsule and tablet of bambuterol: AUC0-1 were (72 +/- 18) and (72 +/- 13) microgram.h.L-1, Cmax were (8.1 +/- 1.8) and (9.2 +/- 2.3) microgram.L-1, Tmax were (3.6 +/- 1.3) and (3.7 +/- 1.0) h, respectively; terbutaline: AUC0-t were (129 +/- 32) and (130 +/- 34) microgram.h.L-1, Cmax were (7.8 +/- 2.2) and (8.5 +/- 2.9) microgram.L-1, Tmax were (5.4 +/- 0.8) and (5.6 +/- 1.1) h, respectively. The bioavaiability of the capsule was (100 +/- 16)% (bambuterol) and (101 +/- 13)% (terbutaline).</p><p><b>CONCLUSION</b>The results demonstrated that the two preparations of bambuterol and terbutaline were bioequivalent by analysis of variance, with two-one sided test at 90% confidential level.</p>