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Chinese Journal of Integrated Traditional and Western Medicine ; (12): 892-895, 2006.
Artigo em Chinês | WPRIM | ID: wpr-331957

RESUMO

<p><b>OBJECTIVE</b>To study the effect of Shenbing Mistura (SM) combined with glucocorticoid on recurrent nephrotic syndrome (RNS) in children and levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in blood and urine.</p><p><b>METHODS</b>The treatment group was treated with SM plus glucocorticoid, the control group with glucocorticoid alone, and a healthy control group was adopted, 30 cases in each group. The clinical effect and recurrence rate were observed, and levels of IL-6 and TNF-alpha in blood and urine were determined before treatment and at the 4th, 8th, 12th week after treatment.</p><p><b>RESULTS</b>Significant difference of IL-6 and TNF-alpha levels in blood and urine was found in either the pre- and post- treatment auto-control of both the treatment group and control group, or in the inter-group comparison of them (P < 0.01); clinical effect also showed remarkable difference between the two groups (P < 0.01). Furthermore, the recurrence rate of the treatment group was lower than that of the control group showed by a 18-month follow-up (P < 0.01).</p><p><b>CONCLUSION</b>SM combined with glucocorticoid could significantly reduce the recurrence rate and elevate the clinical effect in children with RNS, it could also lower the levels of IL-6 and TNF-alpha in patients' blood and urine.</p>


Assuntos
Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Quimioterapia Combinada , Medicamentos de Ervas Chinesas , Usos Terapêuticos , Seguimentos , Glucocorticoides , Usos Terapêuticos , Interleucina-6 , Sangue , Urina , Síndrome Nefrótica , Tratamento Farmacológico , Patologia , Fitoterapia , Prednisona , Usos Terapêuticos , Recidiva , Resultado do Tratamento , Fator de Necrose Tumoral alfa , Sangue , Urina
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