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1.
Journal of Integrative Medicine ; (12): 263-8, 2010.
Artigo em Chinês | WPRIM | ID: wpr-448961

RESUMO

To investigate the effects of Shenqi Jiedu Decoction (SQJDD), a compound traditional Chinese herbal medicine, on expressions of transforming growth factor beta1 (TGF-beta1), smad2 and smad3 proteins in renal tissues of rats with chronic renal failure (CRF) induced by adenine, and to explore the mechanisms of SQJDD in treating CRF.

2.
Chinese Journal of Information on Traditional Chinese Medicine ; (12)2006.
Artigo em Chinês | WPRIM | ID: wpr-578986

RESUMO

Objective To investigate the effect of the Pingshen Tongluo Jiangya granula on the blood pressure and RAS of spontaneously hypertensive rat (SHR). Methods SHR were randomly divided into model group, high dosage group, lower dosage group and captopril group, with normal Wistar rats as control group. Different dosage of Pingshen Tongluo Jiangya granula, captopril and water wes given orally to the rats at the same time of a day for 8 weeks. Blood pressure, AngⅠ, AngⅡ and ALD were determined respectively before treatment and 1, 2, 4, 6, 8 week. Results After eight weeks, the blood pressure of high dosage of Pingshen Tongluo Jiangya granula group had stepped down obviously (P 0.05). It shows that the granula could decrease blood pressure, inhibit the activity of RAS caused by high blood pressure. Conclusion The granula can decrease blood pressure smoothly and steadily, as well as reverse early stage of renal damage caused by high blood pressure.

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