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Objective To retrospectively analyze the epidemiological trend of children with lower gastrointestinal bleeding in recent 10 years,and investigate the change of their disease burden,so as to provide a theoretical basis for the accurate prevention and control of children's lower gastrointestinal bleeding. Methods A total of 671 children with "lower gastrointestinal bleeding" who were diagnosed in our hospital from 2012 to 2021 were collected as research subjects. To analyze the microscopic examination rate and common etiology of lower gastrointestinal bleeding in children in the past 10 years,as well as the epidemiological characteristics of different age groups, different regions and different basic diseases; Calculate and compare the rate of disability life lost (YLD), early death life lost (YLL) and disability adjusted life year (DALY) of children with lower gastrointestinal bleeding within 10 years, and calculate the annual change percentage (AAPC) to analyze the change trend of disease burden. Results The microscopic examination rate of children with lower gastrointestinal bleeding showed a trend of increasing in the past 10 years (P18 years old, hypertension and gastroenteritis. The DALY rate, YLL rate and YLD rate caused by lower gastrointestinal bleeding in the past 10 years showed an upward trend (P<0.05). Conclusion The microscopic examination rate of lower gastrointestinal bleeding in children was graduallyincreasing,and the prevalence rate of basic diseases such as boys,hypertension and gastroenteritis was increasing;in addition,the disease burden caused by children's lower gastrointestinal bleeding was also increasing year by year and should be protected.
RESUMO
Objective To explore the expression of USP39 in tissues of colon cancer (CRC),investigate the association of the expression levels of USP39 and clinicopathological features of CRC patients,and analyze the relevance of USP39 and survival and prognosis of CRC patients.Methods Expressions of USP39 were analyzed by immunohistochemistry in 77 CRC patients.Spearman's rank test,K-M survival curves,and Cox proportional hazards risk were conducted to analyze the clinical relevance of USP39 in CRC.Results Immunohistochemistry revealed that the positive rate of USP39 was upregulated in CRC tissues compare with adjacent tissues Spearman rank correlation showed that positive USP39 expression was significantly associated with TNM stage,lymph node status and venous invasion of CRC patients.Kaplan-Meier curves showed that positive USP39 expression was inversely correlated with 5 years overall and progression-free survival time of CRC patients.Cox proportional hazards risk analysis revealed that USP39 was an independent prognostic factor for CRC.Conclusion USP39 expression is upregulated in tissues of CRC,and USP39 is a potential survival and prognosis biomarker in CRC.