RESUMO
The authors experimentally demonstrated that an aqueous fraction of Drymonia serrulata (Jacq.) Mart. has peripheral, but not central, analgesic activity, and that it also has a dose-dependent anti-inflammatory activity at 24 and 96 hours. The experimental results indicate that the etnomedical use of this plant by the Guaymi Indians may have some scientific validity
Assuntos
Animais , Masculino , Feminino , Anti-Inflamatórios não Esteroides , Plantas Medicinais , Anti-Inflamatórios não Esteroides , Avaliação Pré-Clínica de Medicamentos , Temperatura Alta/efeitos adversos , Camundongos , Edema/induzido quimicamente , Edema/tratamento farmacológico , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico , Panamá , Ratos , Ratos Wistar , Relação Dose-Resposta a DrogaRESUMO
The effect of griseofulvin on lipid constituents and membrane permeability of Microsporum gypseum has been investigated. Mycelia grown in medium containing griseofulvin (IC50 concentration) possessed a lower content of total lipids, phospholipids and sterols. This inhibitory effect was further supported by decreased incorporation of [14C] acetate in total lipids, total phospholipids and sterols. Decrease in total phospholipids was also reflected to a varying extent in all individual phospholipids. An increase in the unsaturated to saturated fatty acid ratio was observed in mycelia grown in medium containing griseofulvin. Membrane permeability was affected by griseofulvin as shown by increased K+-efflux and greater leakage of intracellular [32P] labelled components from prelabelled cells. Our results suggest that the antifungal activity of griseofulvin is partially due to its secondary effect on lipid constituents of Microsporum gypseum.
RESUMO
Thirty patients of chronic cor pulmonale were studied clinically and by chest skiagram, electrocardiography, echocardiography, pulmonary function tests, arterial blood gas analysis and, wherever possible by right heart catheterization. Pulmonary arterial pressures (PAP) correlated significantly only with cardiomegaly on skiagram and with arterial oxygen tension (PaO2). There was no significant correlation between mean PA pressures and prominent pulmonary conus on RVH by ECG, FEV1, PaCO2 or right ventricular outflow tract dimensions by echocardiography. Left ventricular function, as assessed by pulmonary capillary wedge pressure on cardiac catheterization, by LV ejection fraction and fractional shortening on echocardiography was normal in all cases except two (6.67%). There was significant increase in left ventricular posterior wall thickness in the patients studied.