RESUMO
The complexes of Mn, Fe, Co, Ni, Cu, Zn and Cd with some pyrimidine, purine and amino acid ligands have been prepared and tested as feed [food] additives. Bioactivities of complexes have been examined against Salmonella typhimurium and Aspergillus flavus. The present complexes showed no antimicrobial activities against bacteria except Zn-methionine and Co-Ni adenine barbital complexes, which showed antimicrobial activity against Salmonella typhimurium. The chelates showed no antifungal activities, and were more effective against aflatoxin. The antitoxin activity was in the order: Zn-methionine [44.4%] > Zn- barbital and Zn-methionine barbital thiouracil [38.8%] > Co /Ni adenine barbital [27.7%] Mn-methionine barbital > [13.3%]> Mn-barbital [8.3%]. The free ligand [barbital], Cd-barbital, and Cd methionine barbital thiouracil complexes showed no antifungal activities