RESUMO
To evaluate the effect of ocular dominance on stereoacuity in experimentally induced anisometropia. In this clinical trial, 60 healthy adult volunteers 18-37 years of age [mean age: 25.58 years] without any ocular disease were enrolled at Tabriz Nikookari eye hospital over a one-year period. Anisometropia [unilateral myopia] was induced by placing trial lenses over the dominant and non dominant eyes in 1 diopter [D] increments ranging from 1-3 D. Stereoacuity was measured using the TNO, Randot and Titmus stereotests and values were converted into Neperian logarithm [ln] and compared between the two eyes. Of sixty adults including, 25 male and 35 female subjects, the right eye was dominant in 49 [81.7%] of cases. Stereoacuity levels were reduced proportionate to the degree of anisometropia in all participants. Mean stereoacuity was 4.3, 5.5 and 7.4 ln for dominant eyes and 4.1, 5.4 and 7.3 ln for non dominant eyes usig the TNO test by applying 1, 2 and 3 D lenses, respectively [P>0.05]. Corresponding values were 3.5, 4.6 and 6.6 ln for dominant eyes and 3.4, 4.6 and 6.5 ln for non dominant eyes by the circles subcategory of Randot test, respectively [P>0.05]. The scores were 3.8, 4.7 and 6.5 ln for dominant eyes and 3.8, 4.7 and 6.4 ln for non dominant eyes by the circles subcategory of Titmus test, respectively [P>0.05]. Experimentally induced anisometropia could reduce stereoacuity. However, ocular dominance has no effect on the amount of stereoacuity reduction
RESUMO
Macrocysts of S. fusiformis were teased out from the oesophageal muscles of infected buffaloes and a suspension of cyst extract with protein concentration of 2mg/ml was used as uncooked [UE] and cooked [CE] form. Thirty six healthy male laboratory rabbits were divided into six equal groups randomly. Group I and II were inoculated with UE, group III and IVwere inoculated with CE and group Vand VI were inoculated with PBS orally and intraperitonealy [1 ml/kg] respectively. Blood samples were taken in 0, 3, 6, 24 hrs, 3 and 7 days after inoculation. Coagulation tests including BT, CT, PT, APTT, fibrinogen level and platelet count were measured at the different times which mentioned in all groups. Statistical analysis showed significant differences between different times of all tests in group II compare to other groups [p < 0.05]. The study showed that IP inoculation of UE of S. fusiformis at protein concentration of 2mg/ml is lethal to rabbits about 24 hr after inoculation, and caused significant changes in blood coagulation tests in different times. The results also showed that S.fusiformis extract toxin was thermolabile as it was inactivated at 60 ?Cfor 30 min. In addition oral administration of the cysts extract did not make any changes in both cooked and uncooked form. Thus it seems that orally inoculation of S. fusiformis cysts extract had no toxic effects on coagulation tests mentioned above in rabbits because the toxin is probably susceptible to the gastric enzymes and low pH of the stomach