Quaternary ammonium salts of potential biological activity

For possible antimicrobial activity, several quaternary ammonium salts were synthesized which were derived from pyrimidines and 4,7- phenanthroline 5,6-quinone

Reactions with purine derivative: synthesis of arylamino purines of antitumor effects

2,6-diamino, 3,7-dihydro, 7-methyl, [II], 6- amino,3,7- dimethyl, purine, 2-one [III], 6- amino, 3-hydro, 3-methyl, purine, [V] were obtained in one-pot reaction. The derivatives were tested for their antitumour activities

Synthesis of some benzothiazole derivatives of expected biological activity

Denzothiazole was long known to be effective as bacteriostatic, tuberculostatic, fungistatic and molluscicidal agents. The present work describes the synthesis of new 2-methylbenzothiazole derivatives and 2-p[cbloroacetamido] phenyl-6-methylbenzothiazole derivatives which is expected to possess bacteriostatic activity. Treatment of 2-methylbenzothiazolyl magnesium bromide with excess DMF, gave: 2-beazothiazolyl acetaldehyde [I]. The IR spectrum showed a stretching frequencies at 1670 cm[-1] corresponding to C = O group, and the fact that it gave a 2,4-dinitrophenylhydrazone with correct analytical figures. 2-methylbenzothiazolylmagnesium bromide reacted also with ketones and aldehydes to furnish the corresponding hydroxy and carbinol derivatives, [IIa, b] and [IIIa, b]. The IR spectrum showed a stretching frequencies at 3500 cm[-1] corresponding to free OH group

Synthesis of some benzothiazole derivatives of expected biological activity

Denzothiazole was long known to be effective as bacteriostatic, tuberculostatic, fungistatic and molluscidal agents [1-6]. The present work describes the synthesis of new 2-methyl and 2-thiobenzothiazole derivatives which is expected to posses bacteriostatic activity