[Evaluation of efficacy of H. pylori eradication regimens in Iran: a systematic review]

Treatment regimens for the eradication of H. pylori as suggested in Western studies may not be applicable for Iran. Herein, we conduct a systematic review to ascertain the efficacy of eradication therapy regimens used for Iranian patients and introduce the more successful treatment regimens for Iranians. This review was a comprehensive search of English and Farsi electronic databases conducted from June to September 2011. A total of 11 trials were included in our study. In these, there were 28 different eradication regimens studied. Of the 28 regimens, 8 had an H. pylori eradication rate of over 85% and in 3 the eradication rate was greater than 90%. In Iran, the regimens that contained amoxicillin-furazolidone or amoxicillin-clarithromycin for two weeks were the most effective for H. pylori eradication, although the furazolidone-based regimen was less expensive. For first-line treatment, the amoxicillin-furazolidone-based regimen for 2 weeks is cost-effective for H. pylori eradication in Iranian patients

[ effects of whey protein isolate supplement and strength training on weight loss, body composition, strength and muscle hypertrophy in overweight young men]

Limited studies have been conducted on the effect of resistance training plus protein supplements on weight control, muscle growth and body composition. The purpose of this study was to evaluate the effects of a whey protein supplement combined with a 6-week strength training on weight loss, body composition, strength, and muscle hypertrophy in overweight young men. Thirty individuals with a body mass index between 25-30 kg/m[2] participated in the study. They were randomly divided into three groups of 10 persons each as follows: 1. Experimental group 1 [whey supplement + 6 weeks of strength training [W]; 2. Experimental group 2 [placebo + 6 weeks of strength training [D]; 3. Control group [C]. Maximum strength and muscle volume of the subjects were measured by the 1-RM test in bench press, biceps curl, Squats and chest, arm and tight limb. Skinfold thickness [triceps, supraillium, abdomen and thigh] were measured with Lange skinfold calipers. Repeated measure ANOVA and Bonferroni post hoc test were used for data analysis. No significant changes occurred in body weight and BMI [p>0.05]. The waist-to-hip ratio [WHR] also remained unchanged in all groups [p>0.05]. In both the experimental and placebo groups significant reductions in percent body fat and fat mass and significant increases in the lean body mass, strength, and muscle hypertrophy were observed [p<0.05] after 6 weeks of strength training. Strength exercise training alone increases strength, hypertrophy and muscle mass and improves body composition in sedentary, overweight young men. Our results suggest that protein supplementation is not needed for strength improvement or body composition changes

[Low birth weight risk factors survey in neonates in Tehran]

Neonatal mortality rate is one of the main health problems which is affected by prenatal status, maternal, fetal and perinatal conditions. Low Birth weight [LBW] is one of the main causes of neonatal and infantile mortality and is one of the important problems in all of communities. The aim of this study is an evaluation of LBW causes in neonates born to mothers in teaching hospitals in Tehran. This case-control study was conducted to estimate LBW causes in born babies in Taleghani, Mahdieh and Hedayat hospitals, Tehran, Iran Data such as birth weight, sex, maternal age, gestational age, birth interval, history of abortion, prenatal care, maternal occupation, level of education, systemic and underlying diseases, history of infections and smoking were extracted from medical records. Data were statistically analyzed by SPSS ver. 15 using Chi-square, t-test and fisher exact test. 7.7% of neonates were LBW newborns. Maternal age, gestational age, maternal weight and height, and the interval between births of LBW neonates were significantly lower compared with normal birth weight neonates. Multiple logistic regressions model was used to estimate the effects of most important predictors on low birth weight. The logistic model showed that the highest risks for low birth weight were related to low interval between 2 birth [OR=0.54, CI=0.32-0.9 1], Low maternal weight gain during pregnancy [OR=1.4, CI=0.73-2.061], maternal depression or Anxiety [OR=l.62, CI=1.21-2.805]- mother preeclampsia [OR=2.98, CI=2.09-4.32] preterm delivery [OR=3.95, CI=2.38-5.52]. The Results revealed that Low birth weight rates increases in the presence of short interval between two births,-mother preeclampsia, depression or anxiety, and preterm delivery

[Comparision effectivness of extracts of thyme, yarrow, henna and garlic on cutaneous leishmaniasis caused by l. major in animal model [BALB/C]]

Leishmaniasis is not as severe as other diseases, often lesions are selfhealing. For various reason as long lasting duration of lesions and treatment, disfiguring scar reminding, secondary infection in lesions, have comfortable treatment method and accessible with less cost, it is necessary various method of treatment with less side effect. The results of previous studies showed that Indoleanalogues, Terpens, Iridoids, Quinones and Alkaloid hemisynthetic derivatives have promising antileishmanial potential. These derivatives were found in Thyme, Henna Yarrow and Garlic. Access to formulation drug without harmful chemical material and without side effect. After Inoculation of parasite in base tail of mice, during of three weeks caused lesions in inoculation place, then animal divided to 9 groups. In this study we used 4 alchoholic extract solution 2 times a day. we checked lesions weekly for six week and meseaured size of lesion in the base of tail with kulis - vernieh. Data of study analyzed with Anova, Paired t test and schefeh. We observed significant difference between mean of lesion in before and after treatment in control, Yarrow [Bomadaran] and Thyme [Avishan] groups [p<0.05]. Paired t test showed that there were not significant difference between mean of lesion in after treatment between groups of treatment and glucantime groups [p>0.05]. Alchoholic extract to Avishan and Boomadaran have good effect on lesions treatment, we suggest that the study could be repeated with Thyme [Avishan] and Yarrow [Bomadaran] extract in gel or cream base in first stage of lesions appearance

[ frequency of AgNOR [Argyrophilic Nucleoli Organizer Region] points in differentiation between the benign prostatic hyperplasia and prostatic adenocarcinoma]

Background: while the differentiation of prostatic adenocarcinoma and benign prostatic hyperplasia [BPH] is not often a difficult task, sometimes it is not the case even for the experienced pathologists. In this study the efficacy of AgNOR staining technique for differentiating between the prostatic adenocarcinoma and BPH were evaluated

Materials and Methods: using a descriptive study 15 prostatic adenocarcinoma samples [without spot to histologic grade] and 15 BPH samples were selected and stained with AgNOR method. Specimens were taken from paraffin block in Pathology laboratory archive

Results: the average AgNOR points in BPH and prostatic adenocarcinoma were1.39 and 2.48 per cell, respectively. In BPH there were one or two points of AgNOR with specific margin but in prostatic adenocarcinoma numerous arranged AgNOR points were seen. While the number of cells in BPH with three or more AgNOR points were 4.7, in prostatic adenocarcinoma it was 41.47

Conclusion: AgNOR is a useful method to differentiate between benign prostatic hyperplasia and prostatic adenocarcinoma

[ case report of abdominal pregnancy]

Abdominal pregnancy is a very rare condition of ectopic pregnancy with a high mortality rate for mother and fetus. It occurs when the gestational sac implanted outside the uterus, ovaries and fallopian tubes. Although this condition is potential life-threatening but often misdiagnoses of other variant ectopic pregnancy. Prompt detection in initial stage of pregnancy is necessary to prevention of dangerous complication. This present casereport was a patient who admitted in the Alzahra hospital during two decades. She was a 23-year old nulliparous woman with a history of primary infertility that underwent ovarian hyper stimulation with clomiphen citrate. She underwent transvaginal ultrasonography because of menstrual retardation, positive serum betaHCG test and spotting. It was diagnosed an incomplete abortion according to clinical symptoms and lack of gestational sac inside the uterus. Transvaginal ultrasonography was performed again for persistency the pregnancy symptoms after 4months. Diagnostic pelvic ultrasonography confirmed a 16-week intra-abdominal pregnancy. The ultrasonographic examination confirmed a 27-week intra-abdominal pregnancy. The woman was admitted immediately. The surgery was performed, without any complications. She recovered well and was discharged soon

[Expression of Nm23 marker in benign and malignant thyroid neoplasms immunohistochemical]

Several prognostic factors affect the outcome of thyroid carcinomas including tumor stage and distant metastases. Nm23 is a metastasis suppressor gene and has a crucial role in the control of metastatic potential of several carcinomas. The aim of our study is to evaluate expression of nm23 marker in benign and malignant thyroid neoplasms using the immunohistochemistry method and to elucidate its relationship with tumor size, vascular or capsular invasion and lymph node involvement. In a descriptive study, 200 paraffin blocks comprising of 38 benign and 162 malignant thyroid neoplasms stained with nm23 marker were studied. Cytoplasmic staining in more than 10% of cells was considered as positive. The relationship between nm23 and tumor size, vascular or capsular invasion, lymph node involvement was analysed using SPSS 11.5 software [p=0.05]. There was 40% positive incidence of nm23 in follicular adenoma, 87.5% in hurthle cell adenoma, 67.2% in papillary carcinoma, 66.7% in follicular carcinoma, and 64.7% in medullary carcinoma. In follicular adenoma, frequency of nm23 positive tumors was directly correlated to tumor size [p=0.04]. There are no statistically significant correlation between nm23 and tumor size, vascular or capsular invasion or lymph node involvement in malignant thyroid neoplasms. In papillary and medullary carcinoma, negative predictive value of nm23 for lymphnode involvement was over 80%. Also in follicular carcinoma, sensitivity and negative predictive value of nm23 for vascular invasion were approximately 90%. Lack of significant correlation between nm23 and tumor invasiveness [and probably metastasis] factors, demonstrate that although nm23 is a potentially metastasis suppressor gene, whereas in many other tumors it may play a different role in thyroid neoplasms, a role which necessitates further studies to be conducted

[Comparison of the accuracy of diagnostic criteria of behcet's disease in children]

Different criteria for Behcet's diagnosis reveal that there isn't still consensus about the definition of this syndrome. Although a comprehensive study about the accuracy, the sensitivity and specificity of seven different types of diagnostic criteria for Behcet's disease in children, Ras not been performed we planned this study to compare these criteria in the Iranian children with Behcet's disease. Two random samples were selected from the patients less than 16 years of age referring to the Behcet's clinic of rheumatology research center. 177 children had definite diagnosis of Behcet's disease after being visited by the three professors of rheumatology experienced in Behcet's syndrome. Control group were children suspected to have Behcet's disease but it was ruled out. Sensitivity, specificity and accuracy of each of the Behcet's criteria were calculated. Mean age in Behcet's children was 13.6 years and in control group was 12.8 years. In the patients group female to male ratio was 1.1 and in the control group it was 1.3. Sensitivity of different criteria was as follow: Manson and Bames 55.1%, 0' Duffy 60.7%, International criteria 71.9%, Japan criteria 90.4%, Dilsen criteria 79.8%, Iran criteria 93.8%, and Iranian classification tree 94.4%. Specificity of the criteria was as following; M and B 99.5%, O Duffy 99.5%, International 100%, Japan 96.2%, Dilsen 94.6%, Iran 96.2%, classification tree 96.2%. Although some of the researchers believe that current diagnostic criteria of Behcet's diseases due to establishment on the adults clinical data, is not appropriate for children; our study revealed that the current seven Adult BD criteria are reliable and accurate in children too

[Comparison of wear between Iranian resin teeth and ivoclar teeth]

Wearing of acrylic denture teeth creates many problems for patients as well as dentists. Nowadays, artificial teeth are produced by different Iranian companies which compare to their foreign counterparts are more suitable economically. The aim of this study was to compare the amount of wear between Iranian resin teeth and Ivoclar teeth. In this study wear of three types of Iranian resin teeth [Berelian. Marjan, Super newclar] were compared with Ivoclar teeth. Four denture teeth samples were used for each denture teeth. All tests were done in presence of saliva and by using porcelain abrader. The thickness reduction of each sample was measured after 5000 and 10000 cycles with the help of a micrometer. The mean values were compared with ANOVA and T-student test. After 5000 and 10000 cycles there was no significant difference between the mean wear of Berelian teeth and Ivoclar teeth, but after 10000 cycles the mean wear of Ivoclar teeth was decreased and the mean wear of Berelian teeth was increased although this wear was not statistically significant. Comparison of three Iranian resin denture teeth indicated that Berelian teeth showed the least and Super newclar teeth show the maximum amount of wear. The amount of wear in Berelian was almost close to Ivoclar teeth. Therefore we can be hopeful that Iranian companies with improving their production techniques such as mixing the materials, temperature, duration of curing and packing of materials in vacuum can make high wear resistance acrylic teeth

Scleroderma in pediatric age group: Report of 25 cases

Scleroderma is a multisystem autoimmune connective tissue disease, characterized by hardening of the skin. We had 25 patients in the Iranian Pediatric Unit of Rheumatology over 10 years. There was female predominance [F/M = 4/1, 80% female, 20% male]. The age of onest was from 6 months to 16 years, the mean age being 10 years. The symptoms and signs were: nonpitting edema in 16%, hard skin in 80% sclerosis of distal limbs in 72%, facial in 20%, atrophy, and hypopigmentation or hyperpigmentation in 40%,telangiectasis [15%], subcutaneous calcification [10%], Raynaud's phenomenon in 60%, digital ulceration [16%], muscle pain and weakness, arthralgia [30%]. Rarer manifestantion included, dysphagia [16%], dyspnea [8%], cardiovascular disease, pericarditis, cardiomegaly, CHF [16%]. Laboratory abnormalities included: anemia [80%], positive FAN A. > 40 [88%] ESR > 60 [40%] CRP+++ [40%]. Skin biopsy documented increase in the collagen content of dermis in 75%