RESUMO
Diabetes is chronic and progressive disease in which lipid disorder is one of the common disorders which in turn cause the formation of its short-and long-term effects. This study was aimed to examine effect of Kombucha prepared from green tea on blood glucose and lipid profile in diabetic rats. In the present study, 30 alloxan-induced diabetic wistar rats randomly divided in to three groups: 1] control group, 2] diabetic group receiving green tea and 3] diabetic group receiving Kombucha prepared from green tea. Experimental diabetes in rats was induced by intraperitoneal injection of Aloxan [130 mg/kg]. The animals of groupsgreen tea and Kombucha received respectively green tea and Kombucha [made from green tea] and group1 received water 5 ml/kg by oral gavage daily for four weeks. Then glucose and lipid profile were measured. Compared to control group, Serum glucose levels in groups green tea and kombucha were significantly reduced [respectively p=0.002 and p=0.0001]. Compared with green tea, Kambocha decreased glucose significantly [p=0.050]. Increasing concentrations of HDL in kombucha group in comparison with green tea group was significant [p=0.02] and reduction of total cholesterol and LDL concentration in groups kombucha and green tea in comparison with control group was significant. Meanwhile, decreased average total cholesterol and LDL concentration in kombucha group in comparison with grean tea group was also significan [respectively p= 0.0001 and p =0. 0001]. Use of Kombucha caused a decrease in serum glucose, LDL, total cholesterol and an increase in HDL cholesterolthat this effects are probably because of fermentation process products
RESUMO
Pomegranate [Punica granatum L.] is a drought tolerant fruit-bearing deciduous shrub native to Iran. It is widely cultivated in dry areas of Iran. Pomegranate fruit juice contains a wide range of polyphenolic metabolites, especially punicalagins with powerful antioxidative properties. Pomegranate seed oil is a unique natural product and a rich source of conjugated fatty acids. The aim of this study was to investigate the pharmacological effects of fruit juice and seed oil of pomegranate on serum lipid levels of hypercholesterolemic rabbits and development of atherosclerosis on their aortas. Fourthly two males and six months aged white New Zealand rabbits [1.7 -2 kg] were randomly assigned to six equal groups and caged in the same environmental condition. One group was fed on regular animal house rabbit chew. Five other groups fed with high cholesterol diet [1% cholesterol]. One group kept as control and other 4 groups fed on same diet supplemented with 1% and 2% doses of pomegranate fruit juice or seed oil. The whole experiment lasted 2 months. At the end of the study [after 2 months] the biochemical analysis of serum lipids and pathological evaluation of atherosclerotic plaque of aortas were performed. Results of biochemical analyses showed that administration of fruit juice and seed oil at both doses did not significantly affect the level of serum lipids profile of hypercholesterolemic rabbits. Pathological data analysis showed that treatments of rabbits with fruit juice and seed oil at both doses significantly reduced aortic atherosclerotic plaque formation. Pomegranate fruit juice and seed oil administration inhibited atherosclerosis development in hypercholesterolemic rabbit's aortas without any significant effects on lipid profile