Synthesis, characterization and catalytic activity of copper [II], nickel [II] and cobalt [II] complexes derived from novel hydrazone drivatives of oxamic hydrazide

A series of new coordination complexes of Cu[II], Ni[II] and Co[II] with omaxic hydrazide [L[1]], N,N' - [salicylidene]- oxamic hydrazide [L[2]] and N,N' - bis [naphthalidene] - oxamic hydrazide [L[3]] have been synthesized and characterized by elemental analysis, magnetic moment, IR, UV - Vis spectra nd molar conductance. The thermal behavior of the complexes was investigated by TG A and DTA techniques. The catalytic activity of the complexes to decolorize the Allura-Red [food dye] in presence of H[2]O[2] was studied

Inclusion complexes of nicardipine-HCL for oral administration

Inclusion complexes of nicardipine HCl [NIC] with beta-cyclodextrin [beta-CD] and hydroxypropyl-beta-cyclodextrin [HP-beta-CD] were prepared using different methods: co-evaporation, kneading and co-precipitation. Inclusion complexation in aqueous solution and in solid state was studied by the solubility method, Fourier transform-infrared spectroscopy [FTIR], Differential scanning calorimetry [DSC] and X-ray diffractometry [XRD]. The solubility of [NIC] increased as a function of cyclodextrin concentration, showing B s and AL type diagrams for [beta-CD] and [HP-beta-CD], respectively. The dissolution rate of [NIC] / cyclodextrin complexes were investigated and compared with those of the physical mixtures and pure drug. The dissolution efficiency of [NIC] increased by complexation with cyclodextrins to 2.8-2.9 fold than [NIC] alone. Oral bioavailability in rabbits increased to 6 fold by complexation with [beta-CD]

Formulation and evaluation of a transdermal drug delivery system for nicardipine hydrochloride: in vitro and in vivo studies

In the present investigation, nicardipine HCl was formulated in different traditional transdermal formulations that are used topically on the skin for systemic action. These formulations were an ointment, an o/w emulsion, a gel, an emulgel and a cellulose acetate butyrate film. Enhancers; namely, dimethyl sulfoxide [DMSO], Tween 80, urea, cetrimide and sodium lauryl sulfate [SLS], were added in different concentrations to the selected pharmaceutical formulations. In vitro studies were carried out on an isolated abdominal rabbit skin using diffusion cell. The correlation coefficient [r], the steady-state flux [J] and permeability coefficient [kp] were calculated. The results revealed that the permeation of the drug trough the skin was mainly dependent on the composition of each base and the type of the added enhancer and its concentration