Antibiotic concentration into the sinus secretions in case of chronic maxillary sinusitis

The ability of different antibiotics to penetrate into the diseased maxillary sinus mucosa and to sinus secretion was investigated in patients with chronic maxillary sinusitis. 50 patients were given a course either of rifampicin [18 patients], cephalexin [16 patient] or ampicillin [16 patient], 60 aspirated, and 90 irrigated secretion samples were assessed for determination of the concentration of these antibiotice. The highest concentration was achieved with rifampicin and the lowest was with cephalexin