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1.
Bulletin of Faculty of Pharmacy-Cairo University. 1998; 36 (2): 1-9
em Inglês | IMEMR | ID: emr-47779

RESUMO

The biologically active 4H-pyrido [1, 2-a] pyrimidin-4-ones [1] including some hexahydro derivatives [2] are non acidic non-steroidal anti-inflammatory agents. Other pyrido [1, 2-a] pyrimidines were reported as analgetic anti-inflammatory agents [3-8]. In a search of analgetic pharmacophore in condensed pyrimidines, the chemistry and analgetic activity of the bioisoster pyrimido-[1, 2-a] azepine [9] 1 was reported. This work found that ester, carbamate, thiosemicarbazide, semicarbazide, urea and acyl urea groups are of special value in the analgetic activity of 1. On the other h and, it was assumed that any changes in the structure of 1, that might add to its analgetic effect, would be beneficial


Assuntos
Compostos Bicíclicos com Pontes/análogos & derivados , Analgésicos não Narcóticos/síntese química
4.
Bulletin of Faculty of Pharmacy-Cairo University. 1995; 33: 41-6
em Inglês | IMEMR | ID: emr-36678
5.
Bulletin of Faculty of Pharmacy-Cairo University. 1993; 31 (2): 187-90
em Inglês | IMEMR | ID: emr-27549

RESUMO

Five series of the titled nucleus were prepared. Enaminonitrile I reacted with oxalyl chloride and chloroacetyl chloride to afford the tricyclic compounds II and III, respectively. II reacted with various alcohols to give the corresponding ester, also III reacted with various amines to yield the corresponding compounds. The anti-inflammatory effect of some members showed significant results as compared with Diclofenac. Another derivatives were found to inhibit 50% of the histamine induced contraction of guinea pig ileum. It is worth mentioning that the animals treated with the test substances were more quiet and less aggressive than the control


Assuntos
Animais de Laboratório , Pirimidinas/farmacologia
6.
Bulletin of Faculty of Pharmacy-Cairo University. 1993; 31 (2): 191-97
em Inglês | IMEMR | ID: emr-27550

RESUMO

Pyrrolo [1,2-c] pyrimidine derivatives I reacted with various acid chlorides to afford a number of 3-substituted pyrimido [5,4-e] pyrrolo [1,2-c] pyrimidines. The 3-chlorocarbonyl intermediate I-A reacted with different alcohols to give the corresponding esters. Moreover, 3-chloromethyl derivative I-B reacted with thiourea, alkoxides and sodium salts of aromatic acids to yield thiouronium salts, ethers and esters, respectively. Some members were tested as smooth muscle relaxant diuretic and hypotensive activities. It was shown that compound VII-a is the potent as hypotensive and diuretic agent. Also, it was noticed that, while all the test substances inhibit the uterine motility, VII-a stimulates the uterine motility in all stages


Assuntos
Animais de Laboratório , Compostos Heterocíclicos/farmacologia , Hidrocarbonetos Aromáticos com Pontes/química
7.
Bulletin of Faculty of Pharmacy-Cairo University. 1993; 31 (1): 33-8
em Inglês | IMEMR | ID: emr-95500
8.
Bulletin of Faculty of Pharmacy-Cairo University. 1993; 31 (1): 49-53
em Inglês | IMEMR | ID: emr-95503

RESUMO

Dicyanomethylidene 1a and its piperidine analogue 1b reacted with B-chloroethylisocyanate to afford unexpectedly the heterocycles: imidazo [1,2-c] pyrrolo [2,1-f] pryrimidine-10-carbonitrile and imidazo [1,2-c] pyrido [2,1-f] pyrimidine-11-carbonitrile hydrochlorides 3a and 3b respectively. Subsequent hydrolysis gave the corresponding carboxamides 4a,b and carboxylic acids 6a,b. The structures of the new nuclei have been confirmed by chemical and spectral means. Two compounds were subjected to pharmacological testing and have shown 50% inhibition of the histamine induced contraction of guinea pig ileum


Assuntos
Animais de Laboratório , Compostos Heterocíclicos/farmacologia , Hipersensibilidade/tratamento farmacológico
9.
Alexandria Journal of Veterinary Sciences [AJVS]. 1988; 4 (2): 229-35
em Inglês | IMEMR | ID: emr-10026

RESUMO

Forty ewes were vaccinated with Cl. perfringens vaccine during the last third of gestation period and supplemented according to the divided groups: The first group received selenium, the second received vitamin E, the third received both selenium and vitamin E and the fourth group served as control. The injected dose was 5 mg sodium selenite and 400 mg tocopherol. Selenium and /or vitamin E improved the antibody titers for clostridial toxiodes [beta and epsilon] in ewes and their lambs, by their intensification of protein synthesis. Better results were obtained when both selenium and vitamin E used simultaneously with the vaccine


Assuntos
Selênio , Vitamina E
10.
Egyptian Journal of Pharmaceutical Sciences. 1988; 29 (1-4): 587-94
em Inglês | IMEMR | ID: emr-10341

RESUMO

The synthesis of several 3-[4-arylindine-2-alkyl [aryl] 5[4H] imidazolon-1-yl] phenyl]-2-methyl-7-nitro-4 [3H]-quinazolinones are described. Structured establishment of the new compounds is substantiated by element analysis, IR and h- NMR spectra. Preliminary biological screening of some selected members showed no detectable antimicrobial activity in vitro, chloramphenicol and nystatin were included in the study for sake of comparison


Assuntos
Quinazolinas , Química Farmacêutica
11.
Egyptian Journal of Pharmaceutical Sciences. 1988; 29 (1-4): 595-604
em Inglês | IMEMR | ID: emr-10364

RESUMO

Several new 3-substituted 7-nitro-4 [3H] quinazolinones were prepared. The structures of the obtained compounds based on elemental analysis, IR and H-NMR spectra. Anti-convulsant and hypnotic activities of some compounds were tested and compared to phenytoin and pentobarbital sodium


Assuntos
Antimaláricos , Depressores do Sistema Nervoso Central
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