Effect of chlorpromazine and metoclopramide on the secretion of some hormones and central neurohumors in rat

After 3 weeks of daily intraperitoneal [i.p.] administration of cholorpromazine [10 mg/kg] or metoclopramide [0.15 mg/kg] to male rats, the whole brain levels of norepinephrine and dopamine significantly decreased. Serum prolactin, thyroxine and tri-iodothyronine levels significantly increased as compared to control values. Serotonin and ACTH were affected by chlorpromazine only. Brain histamine level did not change in both groups. It was concluded that drugs which after central dopaminergic mechanisms may exert significant influences on the secretion of some adenohypophyseal hormones. Serotonin may partially counteract the effect of dopamine. Brain histamine is unlikely to contribute in an important way to the major action of chlorpromazine and metoclopramide in the secretion of hormones

Immunological studies in patients with breast carcinoma treated with radiotherapy

Several immunologic variables were evaluated in 30 females with breast carcinoma before and after radiotherapy. All patients underwent modified radical mastectomy. Immunologic studies of peripheral blood leucocytes included nitroblue tetrazolium [NBT] positive neutrophils, T-cell count [E rosette], lymphocyte blastogenic response to phytohaemaglutinin [PHA], concanavalin [Con A], Pokeweed mitogens [PWM] and determination of immunoglobulins IgG, IgM and IgA. The NBT positive cells, T-cell count, T-cell response to PHA and PWM were significantly depressed, while responses to Con A was significantly increased after radiotherapy. No significant changes has been noticed in the mean values of IgG, IgM and IgA. Positive correlation has been found between T-cell count and function in responses to PHA and Con A mitogens and prognosis in patients with cancer breast