Helicobacter pylori and non-alcoholic fatty liver disease: Is there a relationship?

Non-alcoholic fatty liver disease (NAFLD) is distinguished by liver injury due to metabolic stress, identified by diffuse hepatocyte macrovascular fatty lesions [1]. The prevalence of NAFLD is rising yearly, with a worldwide incidence rate between 20% and 30% [2]. Complex hereditary variables, improper lipid metabolism, and insulin resistance are the key characteristics of the etiology of NAFLD [3]. The research has revealed that aberrant lipid metabolism in the liver can result in dysbacteriosis in the intestinal flora; abnormality of the flora eventually encourages lipid deposition in the liver. Additionally, there is mounting proof that NALFD is linked to abnormalities in the gut flora, particularly Helicobacter pylori (H, pylori) [4]. Gram-negative bacillus, termed H pylori, has colonized the deep layers of the gastric mucosa. [5]. The global infection rate for H pylori is about 50% or higher [6]. According to research, H pylori causes gastric cancer, gastrointestinal lymphoma, peptic ulcers, and chronic gastritis [7]. Additionally, some researchers indicate a connection between H pylori and liver cancers, diabetes, and improper lipid metabolism [8]. Some studies have discovered that infection by H pylori is one of the elements for NAFLD to progress and that getting rid of H pylori can partially stop the evolution of NAFLD [9].

Hyperuricemia in female and male patients of chronic plaque psoriasis

Objective: To determine hyperuricemia in patients with chronic plaque psoriasis

Methods: Out of 194, 97 biopsy proven patients of psoriasis were taken as cases and 97 participants coming to OPD with any other skin disease like acne, alopecia, dermatomycosis etc. as controls. 5ml of venous blood was drawn in sterile syringe and using gel sample tube was sent to the laboratory for serum uric acid level

Results: There were 54.6% [106/194] male and 45.4% [88/194] female. Patients of psoriasis had hyperuricemia more frequently than controls [25.8% vs. 7.2%]. Although male patients and similar frequency of hyperuricemia as in controls [15.2% vs. 6.7%], female patients had significantly more frequent than controls [35.3% vs. 8.1%]

Conclusion: Hyperuricemia is a common finding in psoriatic patients. Its treatment might be clinically useful for the global treatment of patients. We found a female preponderance which could also be due to the overall more proportion of female patients visiting the clinic

Necrotizing fasciitis caused by aeromonas sobria: a case report

Aeromonas sobria is facultative, oxidase-positive, anaerobic, flagellated gram-negative bacilli. Found commonly in sewage, soil, and blackish or fresh water. Commonly causing various diseases in immunocompromised patient, but in healthy patients causing diarrhea and soft tissue infections. We are reporting a case of incomplete septic abortion and necrotizing fasciitis caused by Aeromonas sobria, which was successfully diagnosed early and managed by aggressive surgical and medical managements