RESUMO
Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in China, in December 2019, and was declared a pandemic by WHO on March 11, 2020. The treatment is evolving and is mostly supportive in nature. Material and methods: This was a single-center retrospective study that included confirmed COVID-19 cases treated at our institute (a tertiary care hospital in Jammu and Kashmir, India), between March 2020 and December 2020. Patients with age more than 18 years were included in the study. Results: On evaluating the effect of various drug therapies used in management of COVID-19 patients of all severity, use of remdesivir and famotidine was associated with significantly higher odds of survival. In subgroup of patients with severe disease, use of systemic steroids was associated with significantly higher odds of survival in addition to remdesivir and famotidine. In patients with severe COVID-19 illness, likelihood of survival was significantly higher in those who received combination of systemic steroids plus remdesivir compared to steroids and remdesivir alone. Conclusion: Steroids were effective in severe COVID-19 illness and the combination of steroids and remdesivir was more effective in severe illness. There is a need to undertake more large scale prospective randomized trials to determine the most effective drug therapies to treat the sick patients and prevent worsening of mild cases.
RESUMO
Background: Quality and safety of prescribing in older people remains a global healthcare concern and inappropriate prescribing is a major public health issue because of its direct association with morbidity, mortality and wastage of health resources in this age group. Very limited data is available on the drug utilization pattern in geriatric population and the present study was carried out to see the prescription pattern in geriatric population in this part of the world.Methods: The present study was conducted by the department of pharmacology in outpatient department of geriatrics in a tertiary care centre to look into the prescription pattern among geriatric age group.Results: A total of 237 prescriptions were collected, out of which 108 (45.56%) were males and 129 (54.44%) were females. The majority of the patients were in the age group of 60-69 years (n=141, 59.5%). The most commonly found comorbidity was hypertension (63.29%) and antihypertensive agents (74.68%) were the most frequently prescribed class of drugs. Calcium (37.57%), budesonide (32.91%), thyroxine (27.84%) and pantoprazole (25.31%) were the most common individual drugs prescribed.Conclusions: Like other studies on geriatric population polypharmacy was also observed in the present study and periodic therapeutic audit is essential to ensure rational medicine use.
RESUMO
Background: Premenstrual syndrome [PMS] is one of the disorders associated with onset of menstruation causing physical, psychological and behavioral symptoms
Objective: To determine the prevalence and risk factors of premenstrual syndrome among female population of Rahim Yar Khan
Methodology: Study Design: Cross sectional study. Study subjects: Females of reproductive age from 16 to 40 years. Place and duration of study: Research was conducted from 16[th] to 29[th] March 2015 that was carried out in OPD and Gynecology ward of Sheikh Zayed Medical College/Hospital, Rahim Yar Khan. Performa was designed and pretested. Before commencing with the data collection, informed verbal consent was taken from all the 300 study subjects. The performa contained information on age, marital status, occupation, educational level of subjects and signs/symptoms of premenstrual syndrome among females. The data was entered on SPSS version 16 and results of various variables were presented as percentage and mean +/- standard deviation
Results: Study subjects has mean age of 22 +/- 4.9 years. Age distribution of subjects was 16-20 years [47%], 21-25 years [38.3%], 26-30 years [7%], 31-35 years [4.3%] and 36-40 years [4.3%]. In this study, 5.7% were illiterate, 3% primary, 3% middle, 7% secondary and 81% were highly educated. In this study, 74% were students, 14% housewives, 10% has government job and 2.3% has private job. In this study, 74.7% were unmarried. Out of 300 females 251 [83.7%] were found to have PMS. Frequency of PMS symptoms in study subjects were anxiety [57.7%], depression [57.7%], mood swing [71.7%], irritability [73.3%], pain [86.7%], fatigue [79.7%], discomfort [83.7%], abdominal cramps [47.7%], breast tenderness [25%], bloating [27.7%] and acne [32.3%]. The frequency of most common risk factor was low cheese/butter intake [87.7%], high tea/coffee intake [74.7%], high salty / junk food intake [66.3%], Low yogurt intake [61%], daily exercise [48%], low milk intake [39%], low egg intake [35.5%], low vegetable intake [13.7%], sedentary life style [33.3%], stressed state [30.3%], and eating spicy/cold food [7.3%]
Conclusion: Premenstrual syndrome was high in study subjects and high in young females. Majority of the women having PMS were unmarried, students and education level above bachelors and has low cheese/ butter intake, high tea/coffee and junk food intake