Randomized controlled trial on effect of Tuina for treatment of sub-health people of somatic pain / 中国针灸

<p><b>OBJECTIVE</b>To evaluate the clinical effect and safety of Tuina for treatment of somatic pain of sub-health.</p><p><b>METHODS</b>A randomized, double-blind and blank parallel controlled trial was done. The experiment group was treated with Tuina and the control group lied down for rest, 45 minutes each time, twice each week for three weeks.</p><p><b>RESULTS</b>Tuina treatment could improve more on sensory, affective, evaluation, pain rating index and extant pain intensity of the pain index, and score of subjective sensation of life quality and health status together with physiology and psychology field of life quality.</p><p><b>CONCLUSION</b>Massage is an effective therapy for treatment of somatic pain of sub-health without adverse reactions and it should be generalized to application.</p>

Relationship between islet autoantibodies and HLA-DQ genotypes in first-degree relatives of autoimmune type 1 diabetes / 中华内分泌代谢杂志

Objective To evaluate the association of islet autoantibodies [ glutamic acid decarboxylase antibody(GADA),protein tyrosine phosphatase antibody(IA-2A)and insulin autoantibodies(IAA)1 with HLA- DQ genotypes in the first-degree relatives of autoimmune type 1 diabetes mellitus.Methods This was a cross- sectional and case-control study.Three hundred and fifty-one first-degree relatives with normal glucose tolerance of patients with type 1 diabetes mellitus and 376 healthy controls were recruited and measured for GADA,IA-2A and IAA by radioligand assay,and 156 first-degree relatives of patients with autoimmune type 1 diabetes mellitus and 278 controls were typed for genetic polymorphisms of HLA-DQ with PCR sequencing-based typing method.Results (1)DQA1*03,DQBI*0303,*0401 alleles and DQA1 * 03-DQBI * 0303,DQA1 * 05-DQBI * 0201,DQA1 * 03-DQBI * 0401 haplotypes were significantly increased in the first-degree relatives of autoimmune type 1 diabetes mellitus(P