Association between total antioxidant status and atherosclerosis in elderly patients with essential hypertension / 中华心血管病杂志

<p><b>OBJECTIVE</b>To investigate the association between plasma total antioxidant status (TAS) and association with brachial-ankle pulsewave velocity (baPWV) in the elderly patients with essential hypertension(EH).</p><p><b>METHODS</b>A total of 133 consecutive EH patients older than 60 years were enrolled and another 92 elderly non-EH healthy subjects served as control. According to blood pressure level, EH patients were further classified into three subgroups. The concentration of plasma total antioxidant status was measured by using chemical luminescence method. High-sensitive CRP, urine microalbumin, uric acid, blood lipids and blood glucose levels were also measured. Carotid intima-media thickness was determined by color Doppler ultrasonography and the degree of arteriosclerosis was investigated with baPWV and ankle-brachial index (ABI).</p><p><b>RESULTS</b>(1) Plasma levels of TAS in EH patients were significant lower than in control group [(1.123 ± 0.126)mmol/L vs. (1.258 ± 0.125) mmol/L, P < 0.05], and were similar among hypertension subgroups (P > 0.05).(2) Stepwise multiple regression analysis showed that age, gender, body mass index, systolic blood pressure, diastolic blood pressure, high-sensitive CRP, UA were dependent variables of TAS. Multivariate regression analysis showed that high-sensitivity CRP, UA were independent factors affecting TAS (β = -0.03, standardized β = -0.01, P < 0.05). (3) Compared with the control group, baPWV was significantly higher in elderly EH patients left baPWV (1914 ± 341) cm/s vs. (1817 ± 322) cm/s, right baPWV (1899 ± 330) cm/s vs. (1772 ± 345) cm/s(P < 0.05)and baPWV tended to increase with the level of blood pressure of EH group (P < 0.05) . (4) After adjusting for age, CRP, UA, partial correlation analysis showed that plasma TAS was negatively correlated with baPWV (r = -0.459, P < 0.05).</p><p><b>CONCLUSIONS</b>Our results indicate that TAS and arterial elasticity are decreased while arterial stiffness is increased in elderly hypertensive patients. The decline in antioxidant capacity may be responsible for vascular damage and arterial elasticity decrease in elderly EH patients.</p>

Relationship between metabolic syndrome and coronary atherosclerosis / 上海第二医科大学学报

Objective To investigate the relationship between metabolic syndrome(MS) and severity of coronary atherosclerosis. Methods Sixty-four hospitalized patients diagnosed as coronary heart disease were divided into MS group(n=26)and non-MS group(n=38).All the patients underwent 16-row multi-slice CT coronary angiography,and cardiovascular risk factors were evaluated. Results The prevalence of MS increased with the number of stenosed coronary arteries(P

Clinical study of flow-mediated dilatation of brachial artery in elder patients with isolated systolic hypertension combined with hyperlipidemia / 上海第二医科大学学报

Objective To investigate the relationship between flow-mediated dilatation of the brachial artery(FMD) and cardiovascular risk factors as well as target organ damage in elder patients with isolated systolic hypertension(ISH).Methods Ninety patients with ISH were divided into two groups: ISH group(n=51) and ISH with hyperlipidemia group(n=39).Color Doppler ultrasound for FMD was performed on all the patients,and carotid artery ultrasound and cardiac ultrasound were also conducted. Results Patiens with hyperlipidemia had lower FMD than those of ISH group(P=0.021).It was revealed by univariate analysis that FMD was negatively related to systolic blood pressure,carotid intima-media thickness and total cholesterol(P

Number of circulating endothelial progenitor cells inversely correlate with the severity of coronary artery disease in patients with stable coronary artery disease / 中华心血管病杂志

<p><b>OBJECTIVE</b>To investigate whether the number of circulating endothelial progenitor cells (EPCs) correlate with the severity of coronary stenosis in patients with stable coronary artery disease (CAD).</p><p><b>METHODS</b>80 consecutive patients who underwent coronary angiography (exclusion of acute coronary syndrome and myocardial infarction) were enrolled. Physical examination and blood tests were performed to assess the disease severity and cardiovascular risk factors. Circulating EPCs as measured by the number of CD133/KDR double positive cells were detected by FACS.</p><p><b>RESULTS</b>The number of EPCs inversely correlated with age, creatinine clearance (Ccr) and left ventricular mass index (LVMI) (P = 0.004, 0.015, 0.014 respectively). Patients with hypertension showed significant reduction in number of EPCs compared to those without hypertension (P = 0.004). Moreover, the number of EPCs in patients with coronary artery disease was significantly lower than that of those with normal coronary artery (P < 0.01). EPCs also inversely correlated with angiographic Gensini score (n = 49, r = -0.305, P = 0.039).</p><p><b>CONCLUSIONS</b>In patients with stable CAD, the numbers of circulating EPCs correlate with the severity of CAD as well as cardiovascular risk factors.</p>