RESUMO
Objective To study the effect of Longxuejie capsule combined with Jiuhua ointment treatment on wound after ring-like mixed hemorrhoid surgery.Methods A total of 107 patients with ring-like mixed hemorrhoid (RMH) were randomly divided into the control group and the treatment group.All the patients were treated with the surgery,and then the control group were treated with Mayinglong ointment,while the treatment group were treated with Longxuejie capsule combined with Jiuhua ointment.The two groups were treated for 10 days.The clinical efficacy of the two groups after treatment were compared.The VAS score,edema degree score,wound drainage score,wound area score and wound granulation tissue score of the two groups were compared before and after treatment.The serum VEGF,PDGF and bFGF of the two groups were compared before and after treatment.The adverse reactions rates of the two groups during the treatment were compared.Results The total efficacy rate of the treatment group was 92.59％ (50/54),which was significantly higher than 77.4％ (41/53) of the control group (x2=4.881,P=0.027).After treatment,the VAS (0.8 ± 0.2 vs.1.6 ± 0.3,t=13.915),edema degree score(0.3 ± 0.2 vs.0.8 ± 0.2,t=12.690),wound drainage (0.2 ± 0.2 vs.0.7 ± 0.2,t=l 3.054),area (0.4 ± 0.2 vs.0.9 ± 0.3,t=10.044) and wound granulation tissue (0.4 ± 0.2 vs.0.7 ± 0.2,t=7.427) of the treatment group were significantly lower than the control group (P＜0.01).After treatment,the serum VEGF (126.43 ± 14.68 ng/L vs.107.78 ± 12.26 ng/L,t=7.126),PDGF (59.42 ± 9.73 ng/L vs.48.27 ± 7.08 ng/L,t=6.767) and bFGF (99.86 ± 12.61 ng/L vs.83.67 ± 11.15 ng/L,t=7.031) of the treatment group were significantly higher than the control group (P＜0.01).Conclusions Longxuejie capsule combined with Jiuhua ointment can promote the recovery of wound of the patients after ring-like mixed hemorrhoid surgery.Its mechanism may be correlated with regulation of the expressions of VEGF,PDGF and bFGF,and promotion of formation of granulation tissue growth and repair.
RESUMO
Objective To study the influence of cilostazol to aspirin resistance in patients with coronary heart disease.Methods A total of 165 patients with coronary heart disease were set apart two groups:group A:coronary heart disease,group B:coronary heart disease by 2-diabetes mellitus,Both group A and group B received 100 mg of aspirin daily for 7 days and no other antiplatelet agent.The blood samples were analyzed by platelet aggregation(PAG)test.Platelet aggregation using adenosine diphosphate(ADP)and arachidonic acid(AA).then two groups were randomized four groups:A1,A2,B1,B2 separately.both group A1 and B1received aspirin 100 mg qd continuely,group A2 and B2 added anther antiplatelet drug cilostazol 50 mg bid,redetected platelet aggregation after a week.compared PAG and AR using statistic methods.Results PAG and AR of group A is lower than group B(P0.05).The PAG and AR of group A2 was significantly lower than group A and group A1(P0.05),the PAG and AR of group B2 is significantly lower than group B and group B1(P