The changes of serum homocysteine, C-reactive protein levels in acute cerebral infarction patients and its clinical significance / 中国基层医药

Objective To investigate the changes of serum homocysteine ( Hcy),C-reactive protein ( hsCRP) levels in acute cerebral infarction patients and its significance.Methods 64 patients with acute cerebral infarction were selected as research group,and 60 healthy volunteers were selected as control group.Detected the acute cerebral infarction patients after 1d,the first 7d,14d Hcy,hs-CRP,total cholesterol,triglycerides,high density lipoprotein,low density lipoprotein levels and the control group the level of these indicators.Results Of total cholesterol,triglycerides,low density lipoprotein of the study group was higher than those of the control group of high-density lipoprotein(t =3.073,2.874,2.015,all P ＜0.05);after admission ld,treatment of the first 7d,14d showed no significant difference between the two groups ( t =2.223,2.268,all P ＜ 0.05 ).Conclusion Hcy,hs-CRP and the occurrence of acute cerebralinfarction was closely related to the development,and testing to determine the severity of the disease for the guide had important clinical significance.

Risk factors and prevention of nosocomial infection in diabetic cerebral infarction / 中国康复理论与实践

@# ObjectiveTo investigate the clinical characteristics of patients,risk factors and preventive measures of nosocomial infection in diabetic cerebral infarction(DCI).MethodsThe clinical data of 124 DCI cases with nosocomial infection and 116 DCI cases without nosocomial infection were analyzed retrospectively.ResultsThe clinical characteristics of nosocomial infection in DCI patients were that large cerebral infarction and severity neurological deficits were very common.The patients always had long hospitalization days and poor prognosis.Invasive operation,antibiotic prophylaxis,severity neurological deficits,fasting plasma glucose,urinary albumin,size of cerebral infarction,albumin/globulin and hospitalization days were the risk factors for nosocomial infection in DCI.Among the patients,nosocomial lower respiratory tract infection was the highest(41.5%),the second one was urinary tract infection(28.1%).The case that both sites of infected was common(8.9%).Klebsiella pneumoniae(16.7%),Pseudomonas aeruginosa(15.9%),Candida albicans(12.1%) and Escherichia coli(12.1%) were the most frequent pathogens.ConclusionThe patient's condition of nosocomial infection in DCI is serious and has poor prognosis.Taking preventive measures according to the risk factors can reduce the infection rate.

Effect of the low level laser irradiation in nostril combined with the electric stimulation of cerebellum on acute cerebral infarction / 中国康复理论与实践

@#ObjectiveTo study the effect the low level laser irradiation in nostril combined with the electric stimulation of cerebellum on acute cerebral infarction.Methods88 patients with acute cerebral infarction were randomly divided into two groups, 45 cases in the study group who were accepted level laser irradiation in nostril combined with the electric stimulation of cerebellum and the normal medicine therapy, 43 cases in the control group who were accepted the normal medicine therapy only. The effects of two groups were observed.ResultsThe scores of the nervous function defect degree and the cerebrovascular dynamics indexes of study group were obviously increased (P<0.05 or P<0.01) compared with those before treatment. The indexes of blood viscosity were significantly decreased compared with those before treatment(P<0.01).However, all these indexes of the control group showed no significantly difference before and after treatment. ConclusionThe low level laser irradiation in nostril combined with the electric stimulation of cerebellum therapy is effective on acute cerebral infarction.It is helpful for early comprehensive recovery of motor function of the hemiplegic limbs.

Clinical and pathological features of meningeal carcinoma / 临床神经病学杂志

Objective To investigate the clinical and pathological features of meningeal carcinoma.Methods The clinical,cerebrospinal fluid(CSF)and immunocytochemistry data of 142 patients with meningeal carcinoma were analysis retrospectively.Results Clinical manifestation:headache were found in 123 cases(86.62%),and dizziness were found in 19 cases(13.38%).26 cases(18.31%)had fever and 10 cases(7.04%)had poor vision.CSF and immunocytochemistry:in all cases,EMA,CK were positive and CD14,GFAP were negative in all meningeal carcinomatosis.99 cases(69.72%)showed low molecule CK(+)and high molecule CK(-).These were adenocarcinoma.33 cases(23.24%)showed high molecule CK(+)and low molecule CK(-).These were squamous cell carcinoma.10 cases(7.04%)showed both high and low molecule CK(+).These were adenocarcinoma and squamous cell carcinoma.In 67 cases(47.18%),primary cancer were found in lungs.Tumors were found in gastrointestinal tract in 23 cases(16.20%),and in breast in 9 cases(6.34%).Other primary cancers were found in endomertrium(1 case),in ovarium(1 case)and in liver(1 case).In 37 cases(26.06%),primary cancer couldn't been found.Among the 105 cases which primary cancer were found,15 cases were drawn out.In other 90 cases,82(91.11%)died from 3 to 14 months after diagnosis.In the cases no primary cancer were found,6 cases were drawn out.In other 31 cases,28(90.32%)died from 2 to 13 months after diagnosis although primary tumor was not found.Conclusions The headache and dizziness are the main symptom.The immunocytochemistry are important in the diagnosis of the meningeal carcinoma.The prognosis of the cases with meningeal carcinoma is serious whatever found or not found primary cancer.

Pathologic features of the ganglioglioma/gangliocytoma in the central nervous system / 临床神经病学杂志

Objective To investigate the pathologic features of ganglioglioma/gangliocytoma.Methods 19 cases of gangliogliomas and gangliocytomas were studied by HE stain, immunohistochemistry and ultrastructural observation.Results (1) The tumor cells presented widespread, derangement distribution, and conglobation in some regions. (2) The tumor cells were similar with ganglion cell, showing multipolar in feature, and had large, irregular nucleoli. The nucleoli were clear. Some tumor cells were bi-nucleated. (3) Neurogliocytomas were Ⅱ～Ⅲ grades according to the standard published by WHO. (4) Immunoreactions showed GFAP (-), S-100 (+) and Synaptophyein (+) in neoplastic cells. (5) Ultrastructure observation showed cytolysosome, ribosome and rough endoplasmic reticulum in the cytoplasm of the neoplastic cells. Abundant mitochondria and dense neuroendocrine granules were also found in these cells.Conclusions Ganglioglioma/gangliocytoma is a rare tumor of central nervous system. Its diagnosis mainly depends on histopathology, special markers of immunohistochemistry and ultrastructural features. The property of neoplasma is related to the component of neurogliocytoma.