The construction of fever sentinel clinic in Shanghai community health service institutions / 中华全科医师杂志

During the COVID-19 outbreak,the fever sentinel clinics were set up in Shanghai community health service institutions, based on the experience of Public Health Preparedness Clinic (PHPC) in Singapore. It is a successful case of rapidly transforming existing medical resources into the emergent use for epidemic prevention and control. This article summarizes the necessity and feasibility of setting up a fever sentinel clinic; the functional orientation, hardware and software configuration and operation mechanism of the fever sentinel clinic in different periods according to the operation results. Meantime, the article also proposes suggestions for future improvement of establishing fever sentinel clinic in different regions in China.

Development of examination index system for general practice training centers with Delphi method / 中华全科医师杂志

Objective:To develop examination index system for the general practice training centers with Delphi method.Methods:Experts in fields of medical education, health administration and various clinical specialties were selected from different regions over the country through the purpose sampling method. Two rounds of expert consultation with Delphi method were conducted in April to May 2019; the content included the importance and availability of the assessment in the theoretical examination indexes of the general practice training center. According to the consultation results, the evaluation index system was developed.Results:A total of 28 experts participated in the consultation, among whom 24 were with senior or associate senior titles and 18 were clinicians. The recovery rates of valid consultation questionnaires of twice rounds expert consultation were 100.0% (28/28) and 96.4% (27/28) , respectively. The familiarity and judgment coefficient were 0.893 and 0.877 in the first round of expert consultation, and 0.948 and 0.952 in the second round. The authority coefficient was 0.885 and 0.950 for the first and second rounds of consultation, respectively. The expert consultation importance and availability coordination coefficient were 0.315 and 0.285 for the first consultation; 0.388 and 0.396 for the second consultation. There were three first-level indexes, including basic theoretical capacity, intermediate theoretical capacity and advanced theoretical capacity of general practitioners; and 13 second-level indexes.Conclusions:In this study the positivity coefficient and authority degree of experts are high; the opinions are relatively concentrated. The consultation results have a high rationality and feasibility, which are applicable for assessment of general practitioner.

Quality of life assessment for elderly residents in Shanghai communities and relevant influence factors / 中华全科医师杂志

Objective To assess quality of life in elderly in Shanghai communities and to analyze relevant influence factors.Methods The quality of life and relevant influence factors of 4 395 residents aged 60 years or older who were registered in the health records of three community healthcare centers in Shanghai were investigated through questionnaire survey.Results Total 4 350 valid questionnaire were retrieved with a response rate of 99.0％.The mean physical component summary scale (PCS) score was (50.1± 10.1) and the mean mental component summary scale (MCS) score was (47.3±7.9).Factors influencing the quality of life in order of importance were depressive symptom(B=-8.41),self-care ability(B=7.45),disease score(B=-1.91),participating in outdoor activities(B=1.89),proportion of medical expenses over income(B=-1.72),social intercourse score(B=-1.48),gender(B=-1.37),education level(B=-1.03) and age(B=-0.93).Conclusion The quality of life in elderly residents of Shanghai is relatively high,but the mental components of quality of life need to be further improved.

Effects of Bupi-Qufeng decoction on serum TIgE and EOS of paitents with atopic dermatitis belonging to spleen deficiency syndrome / 国际中医中药杂志

Objective To study the effect of Bupi-Qufeng decoction on total serum IgE (TIgE) and EOS counts of atopic dermatitis (AD).Methods A total of 101 cases were randomly recruited into a treatment group and a control group.During the treatment both groups were give Danggui-Bohe ointment for external use,and based on this,oral Bupi-Qufeng decoction was added in the treatment group and loratadine in the control group.TIgE level and EOS count were detected both before the treatment and four weeks after the treatment.Results TIgE in the treatment group decreased significantly after the treatment (t=8.0063,P＜0.001),the decreased value of which was larger than the control group (t=3.6434,P＜0.001).EOS count in the treatment group also obviously decreased after the treatment (t=3.0314,P＜0.01) ; the decreased value of which was also larger than the control group (t=3.3331,P＜0.01).Conclnsion Bupi-Qufeng decoction could decrease TIgE and EOS level of AD patient,while the therapeutic mechanism needed further research.

Correlation of preoperative pain threshold and pain tolerance threshold with the intensity of stress reaction induced by endotracheal intubation and skin incision / 中华麻醉学杂志

Objective To investigate the correlation of preoperative pain threshold and pain tolerance threshold with the intensity of stress reaction induced by endotracheal intubation and skin incision. Methods Fifty ASA Ⅰ or Ⅱ women, aged 20-55 yr, undergoing elective abdominal surgery requiring at least a 10-cm-long skin incision under general anesthesia, were studied. The electricity dolorimeter was used to measure the patients' pain sensitivity, including pain threshold and pain tolerance, and a State Trait Anxiety Inventory (STAI) was also used to examine the mental state the day before surgery. Total intravenous anesthesia was performed in all the patients.Anesthesia was induced with TCI of propofol 4 μg/ml (effect-site concentration). After patients lost consciousness,fentanyl 3 μg/kg and vecuronium 0.1 mg/kg were injected intravenously. Tracheal intubation was performed 3 min later and the patients were mechanically ventilated. MAP and HR were recorded and arterial blood samples were taken for determination of plasma concentrations of norepinephrine (NE) at 10 min after entering operation room (T1), immediately before intubation (T2), 2 min after intubation (T3), immediately before incision (T4) and 2 min after incision (T5). The differences in MAP, HR and plasma concentrations of NE before and after intubation and skin incision were calculated. SPSS 13.0 statistical software was used to analyze the correlation of STAI,pain threshold, and pain tolerance threshold with the differences in MAP, HR and NE before and after intubation and skin incision. Results Pain threshold was not correlated with the differences in MAP, HR and NE (P ＞0.05). Pain tolerance threshold was negatively correlated with the differences in MAP (r= - 0.766, r =-0.688,P＜0.05), HR (r=-0.703, r=-0.638, P ＜ 0.05) and NE (r=-0.781, r=-0.781, P＜0.05). The STAI score was not correlated with pain threshold and pain tolerance threshold (P ＞ 0.05) .Conclusion Preoperative pain tolerance threshold is negatively correlated with the intensity of stress reaction induced by endotracheal intubation and skin incision, but there is no correlation between pain threshold and the intensity of stress reaction.

Protective effects of alanyl-glutamine on acute lung injury induced by lipopolysaccharide in rats / 中南大学学报(医学版)

Objective To investigate the effect of alanyl-glutamine (Ala-Gln) on acute lung injury (ALI) in rats induced by sepsis and its mechanisms. Methods Forty healthy adult Wistar rats were randomly divided into a control group, a lipopolysaccharide (LPS)-induced shock group, an Ala-Gln treated group, and a glutamine (Gin) treated group. The control group received an intravenous infusion of 28 mL/kg lactated Ringer's solution(LR). The LPS-induced shock group received an intravenous administration of 25 mL/kg LR, and then 3 mL/kg (6 mg/kg) LPS (L-2880, Sigma, America). The AlaGin treated group received 4.5% Dipeptiven (25 mL/kg, equaling 0.75 g/kg Gin) immediately before 3 mL/kg (6 mg/kg) LPS. The Gin treated group received 3% glutamine (25 mL/kg, 0.75g/kg) immediately before 3 mL/kg (6 mg/kg) LPS. Serum (1 mL) was drawn via the femoral vein or cardiac puncture before LPS injection (T0) and 6 h after the administration of LPS (T1), respectively. All rats were killed 6 h after LPS infusion. The samples of pulmonary tissue and lung lavage fluid were collected after experiments. Tumor necrosis factor-α (TNF-α), interleukin-1β( IL-1β), and interleukin-8(IL-8) in the serum at T0 and T1 were detected by ELISA. Apoptosis in the lung epithelial cells was detected with TUNEL assays. The lung wet/dry(W/D) weight ratio and total protein in the bronchoalveolar lavage fluid (BALF) were measured. Results Six hours after the infusion of LPS (T1), the plasma concentrations of TNF-α, IL-1β, and IL-8 were much lower in the Ah-Gln treated group and the Gin treated group than those in the LPS-induced shock group (P < 0.05). Compared with the LPS-induced shock group, AlaGin and Gin significantly reduced the increase in the lung wet/dry weight ratio (P<0.05) and attenuated the morphological lung damage. Conclusion Intravenous administration of Ala-Gha can effectively protect the lung from sepsis induced injury.

The Study on the Application of Traditional Chinese Kernel Medicine in Hairdressing from Book of Waitai Miyao Fang / 国际中医中药杂志

The author found a lot application of traditional Chinese kernel medicine in hairdressing formulae from book of Waitai Miyao Fang, and thus made an exploration on it.

Isolation and identification of lipide from Setaria italica Ⅰ / 中草药

To study the lipoidal constituents of Setaria italica Beauv..Methods　The constituents were isolated by chromatography and structurally elucidated on the basis of spectral analysis.Results　The three glycerides were isolated as dilinolein (Ⅰ)， monolinolenin (Ⅱ)，α, β-digalactosyl-α′-linolenic-glyceride (Ⅲ).Conclusion　These compounds were obtained from the plant for the first time. Compound Ⅲ is a new glycolipin.

Isolation and identification of lipoidal constituents in Setaria italica (Ⅱ) / 中草药

Object To study the lipoidal constituents in Setaria italica (L ) Beauv Methods Individual compounds were isolated by chromatography and their structures elucidated by spectral analysis Results Two lipoidals were further isolated They were identified as glycerol-?, ?-dilinolenate-?′-rhamno-rhamnoside (Ⅰ) and 1-monoolein (Ⅱ) Conclusion The two compounds were obtained from this plant for the first time and compound Ⅰ is a new compound