Pharmacological interactions between ondansetron, an antiemetic drug, and some neuromuscular blockers, succinyl-choline, mivacurium and atracurium

This study was designed to evaluate the effect of the antiemetic ondansetron [5-hydroxytryptamine subtype 3 receptor antagonist] on the onset, potency and recovery rate of succinylcholine, mivacurium and atracurium induced neuromuscular blocking effect both in vitro and in vivo experiments. The study showed that ondansetron should be administered cautiously to the patients using the muscle relaxants [succinylcholine, mivacurium and atracurium] to protect against its initial depolarizing effect and the possible interference with the potency and the rate of recovery of muscle relaxation during surgical procedures