RESUMO
Osteoporosis [OP] is a disease characterized by disruption of trabecular bone structure and loss of its minerals, which increase the risk of fracture. Estrogen deficiency is a critical factor that leads to many problems in women. The present study was carried out to investigate the effect of pomegranate juice and bisphosphonate [risedronate sodium] alone or in combination on ovariectomy-induced osteoporosis in rats. A total of 126 adult female rats were subjected to abdominal operation under a sterile condition. 54 rats were divided into three groups [18 rats each]: Gp. [l] served as control [sham], Gp. [2] received pomegranate [sham+p], Gp. [3] received risedronate sodium [sham+R]. The remained 72 rats were subjected to ovarictomy and then divided into equal 4 groups [4-7]. Gp [4] remained ovarictomized and served as positive group [OVX], Gp. [5] received-pomegranate [OVX+P], Gp. [6] received risedronate sodium [OVX+R] and Gp. [7]: received pomegranate and risedronate sodium [OVX+P+R]. All treatments were started at the 1[st] day of operation and the experiment lasted for 8 weeks, Estradiol, progesterone, parathyroid and calcitonin hormones were assayed as well as serum alkaline phosphtase, ingornic phosphorus and T.calcium. Bone mineral density BMD and bone density [BD] were also recorded: The results revealed that pomegranate juice play a very important role in preventing all the problems accompanied ovariectomy due to its rich content of polyphenols and estrogens like effect