RESUMO
Acrylamide [ACR] is a known industrial neurotoxic and carcinogenic chemical in rodents. The recent discovery of acrylamide in wide variety of commonly consumed foods has energized research efforts worldwide to define toxic mechanisms. The present study is carried out to investigate the effect of acrylamide administration on in vivo malondialdehyde [MDA, a product of lipid peroxidation], reduced glutathione [GSH] as well as copper and zinc superoxide dismutase enzyme activity [Cu/Zn SOD] of rats. Fourteen adult male Sprague Dawley rats were divided into two groups each containing "7" rats. Group I served as negative control fed on basal diet and group 2 [positive control] received basal diet and acrylamide [0.34 g/ kg diet] for 11 days. Levels of MDA, GSH and activity of SOD were determined in liver, kidneys, brain, heart, testes, spleen and lungs of rats. ACR treatment significantly increased MDA in all organs; the highest increase was detected in testis [87.9%] and heart [71.5%] while the lowest one was found in kidneys [28.2%]. On the other hand, GSH levels and SOD activities were significantly reduced in ACR treated rats. However, the reduction of GSH level ranged from 10.2% to 36.5%.The inhibition of SOD activities were higher in testis [57.3%] and lungs [38.5%]. The present study showed that ACR exerts deteriorated effects on oxidative status of rats