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SPJ-Saudi Pharmaceutical Journal. 2010; 18 (2): 107-110
em Inglês | IMEMR | ID: emr-129309

RESUMO

Granulocyte-colony stimulating factor [G-CSF] is a lineage-restricted hematopoietic growth factor. It induces proliferation and maturation of neutrophilic precursors and progenitors and activates neutrophil functions. It is used to ameliorate or prevent profound neutropenia and its consequences. G-CSF therapy in neutropenic disorders increases neutrophil count and improves infectious complications. However, it is not without side effects. Here, we discuss the case of a 2 years old patient with Kostmann's disease who developed cataracts following high-dose G-CSF therapy. We also review the relevant literature on G-CSF-related complications


Assuntos
Humanos , Masculino , Células-Tronco Hematopoéticas , Literatura de Revisão como Assunto
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