Visual results following intravitreal bevacizumab in neovascular age-related macular degeneration

To determine the visual and anatomic outcome of intravitreal Bevacizumab injection in the treatment of neovascular age-related macular degeneration [AMD]. Quasi-experimental study. Layton Rahmatulla Benevolent Trust Eye Hospital [LRBT], Lahore, from January to July 2010. Patients who received, one or more intravitreal Bevacizumab injections [1.25 mg per 0.05 ml] for exudative AMD were included in the study. Outcome measures included standardized visual acuity, optical coherence tomography [OCT], macular thickness, intraocular pressure, and blood pressure at 24 or more weeks follow-up. Descriptive statistics were obtained. Fifty eyes with exudative AMD were observed for six months. The mean VA improved from 0.21 +/- 0.11 before injections to 0.43 +/- 0.11 after injections at six months. Overall, mean OCT macular thickness decreased by 99 micron at last follow-up. At last follow-up, all eyes received an average of 3.28 +/- 0.85 injections. There was no incidence of severe vision loss or adverse effects like endophthalmitis or retinal detachment. Intravitreal Bevacizumab has the potential for improvement of vision in exudative AMD for at least 6 months

Accuracy of the retinal nerve fiber layer measurements by stratus optical coherence tomography for perimetric glaucoma

To calculate the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of measurements of the retinal nerve fiber layer using the Stratus optical coherence tomography in glaucoma subjects with visual field defects on achromatic perimetry as the gold standard. Comparative cross-sectional. Outdoor clinic of Layton Rehmatulla Benevolent Trust Hospital [LRBT], Lahore, from August 2007 to January 2008. Fifty normal subjects and 50 glaucoma patients were selected from outdoor clinic of LRBT. Retinal nerve fiber layer thickness [RNFL] of all the subjects were measured by Stratus optical coherence tomography [OCT]. Visual field defects on achromatic perimetry was used as the gold standard. The sensitivity and specificity of retinal nerve fiber layer measurement for perimetric glaucoma using the OCT were 82% and 96% respectively. The positive predictive value, negative predictive value and diagnostic accuracy were 95%, 84% and 89% respectively. There is a high sensitivity and specificity of RNFL measurements using the new Stratus OCT for the diagnosis of perimetric glaucoma