RESUMO
AIDS caused by HIV-1, is a major threat to human being. An anti-HIV formulation from Chinese herbs, so called "Qu Du Zeng Ning", have been recently developed. In this work, the pharmacodynamics of the formulation in vitro was studied. The results showed that Qu Du Zeng Ning inhibit the replication of HIV-1 efficiently in all cell-based assay, with IC50 at 105.2, 70.7, 77.4 microg mL(-1), separately. A significant synergy between the formulation and zidovudine (AZT) was observed, and it also showed a potent activity against HIV-1 drug-resistant mutant.
Assuntos
Humanos , Fármacos Anti-HIV , Farmacologia , Células Cultivadas , Virologia , Combinação de Medicamentos , Farmacorresistência Viral , Sinergismo Farmacológico , Medicamentos de Ervas Chinesas , Farmacologia , Inibidores da Protease de HIV , Farmacologia , HIV-1 , Fisiologia , Concentração Inibidora 50 , Plantas Medicinais , Química , Scutellaria , Química , Replicação Viral , Zidovudina , FarmacologiaRESUMO
AIDS caused by HIV-1, is a major threat to human being. An anti-HIV formulation from Chinese herbs, so called "Qu Du Zeng Ning", have been recently developed. In this work, the pharmacodynamics of the formulation in vitro was studied. The results showed that Qu Du Zeng Ning inhibit the replication of HIV-1 efficiently in all cell-based assay, with IC50 at 105.2, 70.7, 77.4 microg mL(-1), separately. A significant synergy between the formulation and zidovudine (AZT) was observed, and it also showed a potent activity against HIV-1 drug-resistant mutant.