Paraoxonase inhibition by propranolol

There are many evidences that human serum paraoxonase activity modifies plasma lipid profile and paraoxonase has an antiatherogenic property. Non-selective beta-blockers affect plasma lipid profile too, but they have atherogenic property when patients take these drugs in long term. In this study the effect of propranolol, a non-selective beta-blocker, on paraoxonase activity was investigated. Lineweaver-Burk and secondary plots were drawn and showed that propranolol is a mixed non-competitive inhibitor of paraoxonase