Significance of serum pepsinogens in atrophic gastritis

Chronic atrophic gastritis is a precancerous lesion. A commonly used test for the diagnosis of chronic atrophic gastritis, gastric endoscopy with biopsy collection, and a good serological test would be best include low levels of pepsinogen I [PGI] or a low PGI/PGII ratio. To confirm the use of serum pepsinogens as a screening marker in atrophic gastritis. A study was conducted in the period between December 2005 and March 2006 on 25 patients with artophic gastritis attending Gastroenterology and Hepatology Teaching Hospital in Baghdad, and 25 healyh control subjects. Sera were tested for PGI and PGII by ELISA test the serum PGI were decreased significantly with artophic gastritis and the PGI/PGII ratio were decreased in [78%] of patient group and not affected in healthy people

Association between Helicobacter pylori infection and atrophic gastritis

Helicobacter pylori [H. pylori] infection is associated with gastritis and may induce atrophic gastritis have specific circulating immunoglobulin G [IgG] antibodies. To confirm the correlation between Helicobacter pylori infection and gastric atrophy. A study was conducted in the period between December 2005 and March 2006 on 25 patients with atrophic gastritis attending Gastroenterology and Hepatology Teaching Hospital in Baghdad, and 25 healthy volunteers who agreed to donate blood. Sera were tested for H. pylori IgG Ab by ELISA test. Detection of H. pylori IgG Ab were applied to each individual, showed that [92%] of patients with atrophic gastritis had positive H. pylori IgG Ab were as only 4 [16%] of normal healthy individuals had positive H. pylori IgG Ab