RESUMO
Objective: To explore the material basis and hepatoprotective mechanism of Sini Powder in the treatment of chronic hepatitis, fatty liver and liver cancer based on network pharmacology, and reveal the molecular mechanism of Sini Powder in the treatment of liver diseases "treating different diseases with same treatment". Methods: The effective chemical constituents and targets of Sini Powder and the disease targets of chronic hepatitis, fatty liver and liver cancer were searched by TCMSP, CTD, Genecards, Omim and related literatures. The potential targets of hepatoprotective effect of Sini Powder were obtained by TBtools software, the interaction network of "effective chemical composition-target" and potential target proteins was constructed by Cytoscape 3.7.2 software, and the potential targets were annotated by Uniprot database. David database was used to analyze GO biological function and KEGG pathway enrichment of potential targets. Results: A total of 137 effective chemical constituents, 223 targets, 478 targets for chronic hepatitis, 17277 targets for fatty liver, 16930 targets for liver cancer, and 30 potential targets for hepatoprotection were obtained. GO biological function and KEGG pathway enrichment analysis showed that a total of 178 biological processes and 51 pathways were involved in potential targets. Among the top 20 pathways, nine pathways were related to liver disease. Conclusion: Sini Powder may play a protective role in liver by regulating potential targets such as IL-6, VEGFA, EGFR, PPARG, CASP3 and HIF-1, TNF, PI3K-Akt and other related signaling pathways to exert the functions of anti-inflammation, anti-oxidative stress and inhibition of apoptosis in order to protect liver.