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Chinese Journal of Applied Physiology ; (6): 213-215, 2003.
Artigo em Chinês | WPRIM | ID: wpr-339635

RESUMO

<p><b>AIM</b>To study the influence of astragalus and zinc sulfate on the viscosity in erythrocyte membrane during intestinal I/R and their mechanism of action.</p><p><b>METHODS</b>Models of rabbits intestinal I/R injury were made. The effect of astragalus and zinc sulfate on the viscosity and malondialdehyde (MDA) in erythrocyte membrane, superoxide dismutase (SOD) in erythrocyte, oxidase (XO) in plasma and MDA tissues homogenate were observed.</p><p><b>RESULTS</b>The administration of astragalus and zinc sulfate decreased viscosity and MDA and XO, prevented the reduction of SOD, and alleviated I/R injury.</p><p><b>CONCLUSION</b>Lipid peroxidation injury of the erythrocyte membrane was one of the pathogenesis of I/R injury, and astragalus and the zinc sulfate possessed effects of anti-lipid peroxide, stabilized erythrocyte membrane, increased red blood cell deform ability and raised microcircular perfusion.</p>


Assuntos
Animais , Feminino , Masculino , Coelhos , Astrágalo , Viscosidade Sanguínea , Medicamentos de Ervas Chinesas , Farmacologia , Membrana Eritrocítica , Intestinos , Patologia , Peroxidação de Lipídeos , Malondialdeído , Oxirredutases , Traumatismo por Reperfusão , Metabolismo , Patologia , Superóxido Dismutase , Sulfato de Zinco , Farmacologia
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