RESUMO
Many drugs administered for the purposes of anesthesia and sedation, possess potentially important immunomodulatory effects. Most data in this area is experimental. However, developments in this emerging field are worthy of consideration in the light of their future therapeutic potential. This study was designed to determine the effect of using different induction drugs on adhesive molecules plus the anti-inflammatory cytokine 5nterleukin-10 [IL-10] in pediatrics undergoing cardiac surgeries. 45 pediatric 0.1]. Starting after induction [T2] till 4 hours after operation [T6], Ketamine and sevoflurane groups showed significant lower serum soluble intercellular adhesion molecule-1 [sICAM] level compared with Etomidate groups [P <0.0001]. There were statistically increased IL-10 level in ketamine group at T4, T5, T6, compared to the other two groups. Conclusion: In contrast to etomidate anesthesia, ketamine and sevoflurane reduce the up-regulation of slCAM-1 level; therefore the inflammatory response can be attenuated. Only ketamine can potentiate the anti-inflammatory defense through increasing the IL-10 in pediatric patients undergoing cardiac surgeries