RESUMO
Thirty asymptomatic normotensive obese subjects, body mass index [BMI] > 30 kg/m[2] [14 +/- 46.7%] males, 16 [53.3%] females, mean age 32.9 +/- 6.5 years] and 20 well matched healthy lean control subjects [9]45%] males, 11[55%] females, mean age 31.3 +/- 5.2 years] underwent an echo-Doppler study to evaluate the effects of obesity on systolic as well as on diastolic function. There was no significant difference in heart rate [HR], systolic or diastolic blood pressure [SBP.DBP] between both groups [P=NS]. When compared with the lean group, the obese group exhibited a significantly greater end-diastolic diameter [EDD] [4.9 +/- 0.2 Vs 4.4 +/- 0.3, P<0.01]. end diastolic volume [EDV] [125.5 +/- 28Vs 92.5 +/- 27 P<0.01], stroke volume [SV] [83.4 +/- 19 VS 59.6 +/- 17. P<0.01].Cardiac output [CO] [5.9 +/- 1.1 VS 4. 1 +/- 0.9 P<0.01]. left atrial diameter [LA] [3.7 +/- 3.1Vs 3.2 +/- 2.8.P<0.01]. posterior wall thickness [PWT] [1.1 +/- 0.7Vs 0.81 +/- 0.6. P<0.01] and left ventricular mass index [LVMI] [153 +/- 24Vs94 +/- 26, P<0.01]. There was no significant difference in end-systolic diameter [ESD], end-systolic volume [ESV], septal wall thickness [SWT], percentage of fibre shortening [FS] and ejection fraction [EF] between both groups [P=NS]. Pulsed wave Doppler echocardiographic filling indices were used to evaluate left ventricular [LV] diastolic filling. The obese group had a significantly higher peak velocity of atrial filling [A velocity] [57 +/- 14 Vs 49 +/- 13, P< 0.01], early / atrial filling velocity ratio [E/A ratio] [1.21 +/- 0.25 Vs 1.46 +/- 0.21. P<0.01] time velocity integral of atrial filling velocity [Ai] [4.6 +/- 1.7Vs 3.2 +/- 1.1 P<0.01] and percentage of atrial contribution to total ventricular filling [%AC] [33 +/- 6 Vs 24 +/- 3 P<0.01] Peak early filling velocity [E- velocity] was insignificantly lower in the obese group than the control group [P=NS]. insignificant prolongation of the deceleration time of peak early filling velocity [E-dec.] [P=NS] and insignificantly higher time velocity integral of early filling velocity [Ei] and total time velocity integral [Tvi] [P=NS]. Correlation studies revealed that the BMI was significantly correlated with Ai and% AC [r=0.62. p<0.05] and [r=0.48.P<0.01] respectively