RESUMO
Introduction: Juvenile idiopathic arthritis [JIA] is a chronic autoimmune disease of unclear etiology. It is the most common inflammatory arthritis worldwide with major individual and health service coast. GSTs play important roles in detoxification mechanisms. It is known to be polymorphic and the presence of polymorphisms has been implicated in susceptibility of JIA
Aim: The aim of this study was to explore the association between GST gene and susceptibility to JIA
Subjects and methods: 40 patients with JIA and 40 apparently healthy controls matched with age and sex were genotyped using allelic discrimination by PCR
Results: the frequency of GSTM1 null genotype polymorphism was significantly higher in JIA patients than in controls [OR= 0.4, CI= 0.16-0.98, P= 0.04]. No significant association was found regarding GSTT1 null gene polymorphisms in JIA patients [OR= 0.417, CI- 0.15- 1.13, P= 0.8]. GSTMlnuII gene polymorphism is more prevalent in females than males [P= 0.004], whereas no significant association was found in GSTT1 gene polymorphism [p= 0.4]
Conclusion: Higher frequency of GSTMI null genotype polymorphism in patients of JIA suggesting that it might be associated with susceptibility of JIA, severity and outcome. GSTTI null gene polymorphism had no association with JIA susceptibility
RESUMO
This work aimed to assess ocular changes that may occur in pediatric nephrotic syndrome and chronic renal failure to verify the importance of ophthalmologic examination as a prognostic and follow up parameter in pediatric chronic renal diseases. It was conducted on 121 patients with chronic renal diseases [50 with nephrotic syndrome, 40 were on steroid treatment [group A] and ten weaned from any medications [group B]] in addition to 71 patients with chronic renal failure [21 were on conservative treatment [group C] and 50 were on regular hemodialysis [group D]]. Ocular evaluation of group A revealed decreased visual acuity, recurrent infections and posterior subcapsular cataract. Patients of group B showed cataract, decreased acuity and recurrent infections. The examination of patients of group C revealed decreased acuity and snowflake cataract and glaucoma. It could be concluded that patients with chronic renal diseases were at an increasing risk of ocular affection likelihood cataract, glaucoma, decreased visual acuity, recurrent infections and corneal calcification, especially children with renal failure on long duration hemodialysis and nephrotic syndrome patients under maintenance steroids for long duration