Serum zinc level in patients with simple febrile seizure

To evaluate the serum zinc level of the patients with simple febrile seizure and compare them with febrile children without seizure. This prospective case - control study was performed on 60 patients aged 6 months to 6 years from Apr. 2009 to Jan.2010 in Ghaem, Imam Reza and Dr. Sheikh Hospitals in Mashhad. The serum zinc level was assessed and compared between the cases [30 individuals who suffered from simple febrile seizure] and the controls [30 individuals who had fever without seizure]. Mean serum zinc level was 663.7 micro/l and 758.33 micro/l in the case group and the control group, respectively [P<0.001]. It was revealed that the serum level of zinc was significantly lower in children with simple febrile seizure in comparison with febrile children without seizure

Proteus syndrome: a case report

Proteus Syndrome is an extremely rare, sporadic and progressive disorder. We describe a four-month-old male baby with central nervous system manifestations in this article. A four-month-old boy was admitted into our hospital with three tonic- clonic generalized seizure attacks which started from the day before admission. Each seizure attack lasted less than 10 minutes and the baby was well between attacks. No fever was detected. On physical examination, abnormal facial features, macrocrania, a wide nasal bridge, overgrowth of the right lower limb, macrodactyly in the third left toe, epidermal nevus on the left side of the abdomen and skin vascular abnormalities were detected. His developmental status was normal. Brain Magnetic Resonance Imaging [MRI] revealed left sided hemihypertrophy, ventricle enlargement and macrocrania on the same side

effect of ibuprofen on intractable epileptic attacks in children

Background and Purpose: It seems that during seizures special inflammatory processes remain in the epileptic tissues and can induce still another attack. Based on this hypothesis many studies have been conducted to determine the efficacy of non-steroidal anti-inflammatory drugs on controlling seizures and have obtained different results. so we decided to perform this research. Therefore the present research was conducted to investigate the effect of ibuprofen on controlling intractable epileptic attacks in children

Methods and Materials: This quasi-experimental double-blind study was conducted in 2006-2007 on 30 patients [3-13 years old] with intractable epilepsy. The patients were observed for one month; then they were given ibuprofen syrup [30 mg/k/day divided into 3 doses] for two months; taking ibuprofen syrup was paused for one month; placebo was given for two months with a similar dosage. Patients simultaneously received their previous anticonvulsant drugs during the study period. In each stage the frequency duration and probable complications of each attack were recorded. The obtained data were analyzed in SPSS using paired t-test and chi-square

Results: Patients' mean age and mean seizures onset age were 7.23?3.22 and 2.73?2.43 years respectively. Partial complex epilepsy occurred in 13 cases [43.3%] and 17 patients [56.7%] experienced myoclonic epilepsy. Ibuprofen decreased frequency of attacks in 8 cases [26.7%] and even stopped them in 4 cases. However placebo just decreased attacks in 4 cases [13.3%] but the observed difference was not statistically significant [P=0.434]

Conclusion: Based on the findings there was no statistically difference between effects of Ibuprofen and placebo on controlling epileptic attacks