Effect of the ioversol on early renal function in patients undergoing cerebral vascular intervention / 中国医师杂志

Objective To investigate the effect of different doses of ioversol on renal function,and to explore early renal injury biomarkers on contrast induced kidney injury and safe ioversol dosage.Methods A total of 158 cases (98 males and 60 females) undergoing cerebral vascular intervention (CVI) in our department was selected with age ranging from 23 to 81 years old (average age 59.70 ± 12.02).Based on ioversol dosage in surgery,patients were divided into three groups:low dose group (≤ 150 ml,n =49),middle dose group (151-200 ml,n =74),and high dose group (＞200 ml,n =35).U-κ,U-λ,urinary transferrin (UTRF),urine microalbumin (UMA),urinary immunoglobulin IgG (UIgG),urine beta2-microglobulin (Uβ2-MG),Uα1-MG,urinary N-acetyl-beta-D-glucosaminidase (UNAG),plasma cystatin C (CysC) and Scr were detected by scattering turbidimetry,immune turbidimetry and fully automatic biochemical analysis pre-surgery 24 h and post-surgery 72 h.Contrast-induced acute kidney injury (CI-AKI) was defined as laboratory increase of Scr value≥44.2 μmol/L or ≥25％ from baseline measurement at 48 hours after surgery.The relationship in ioversol dosage and various factors was assessed by Single and multiple factors binary logistic regression analysis.Results According to the criterion that Scr increase value were ≥44.2 μmol/L,of 158 cases,3 cases occurred CI-AKI,the AKI incidence was 1.90％.Based on the criterion that Scr increase value was ≥25％,33 cases occurred CI-AKI,the incidence was 20.89％.The concentration of U-κ,UTRF,Uα1-MG,UNAG and plasma CysC were significantly different in high dose group compared to low ioversol dose group (P ＜ 0.05),while the other biomarkers had no significant difference (P ＞ 0.05).Conclusions The contrast media-ioversol could lead to CI-AKI;when the dosage of ioversol was more than 200 ml one-time,the concentration of U-κ,UTRF,Uα1-MG,UNAG and plasma CysC increased significantly.U-κ,UTRF,Uα1-MG,UNAG and plasma CysC could predict the early renal injury in patients who undergoing CVI.The rise of U-κ,UTRF,Uα1-MG,UNAG and plasma CysC are related to the dosage of ioversol.Furthermore,possibility of kidney injury is significantly high when ioversol dosage is more than 200 ml one-time.

Effect of Insight Education and Self-Confidence Training on The Quality of Life and Well-being Rating in First Episode Schizophrenia / 中国康复理论与实践

@# Objective To explore the effect of insight education and self-confidence training on the quality of life and well-being rating of first episode schizophrenia. Methods 96 inpatients with first episode schizophrenia were randomly divided into the observed group (48 cases) in which patients were treated with risperidone plus insight education and self-confidence training and the control group (48 cases) in which patients were treated with risperidone only. These patients had been treated for 8 weeks and followed up for 0.5 year after discharged. The assessments included the Positive and Negative Symptoms Scale (PANSS),WHO QOL-100,General Well-Being Schedule (GWB) and the Self-Esteem Scale (SES) before the treatment and at the end of the following-up. Results The scores of PANSS, QOL-100, GWB and SES in both groups didn't show significant difference before the treatment (P>0.05). At the end of following-up, the total score, negative score and positive score of PANSS in the observed group were lower than that in the control group (P<0.01), while the total score of QOL-100, areas of mentality, dependence, social relation factor scores, the scores of GWB and SES in the observed group were higher than that in the control group(P<0.05 or P<0.01). Conclusion The insight education and self-confidence training can help to improve the symptom of first episode schizophrenia and enhance their quality of life and well-being rating.

A Study on Infection and Colonization of Mycoplasma genitalium and Ureaplasma ureafyticum in Dif- ferent Male Populations / 中华皮肤科杂志

Objectives To investigate the infection and colonization of Mycoplasma genitalium and Ureaplasma urealyticum in different male populations, to explore the association of M. genitalium and U. urealyticum with nongonococcal urethritis (NGU) respectively. Methods A case-controlled, cross sectional study of four different male populations was performed, namely: NGU patients (G1), non-NGU subjects attending STD clinic (G2), men who had sex with men participating in a health education program (G3), and healthy volunteers (G4). Nested PCR and culture were used to detect U. urealyticum. Nested PCR and PCR product sequencing were applied to detect M. genitalium. Results The prevalence rates of M. genitalium in the four study populations were 25.0%(25/100), 6.4%(6/94), 5.5%(6/110) and 0% respectively. Significant difference was found between each two groups except G2～G3 with a p value of 0.80. By multivariate regression analysis, controlling for the age of first sex, new sexual partners, urethritis and condom use in the previous 3 months, M. genitalium was only associated with urethritis (P= 0.004, OR = 6.754, 95% CI 1.833～24.893). The direct sequencing of PCR products showed gene mutations, in comparison with the reference sequence in GenBank, in 3 samples. The prevalence rates of U. urealyticum by PCR in 4 groups were 40.0%, 44.7%, 22.7% and 46.9% respectively, and there was no significant difference between G1～G2, G1～G4 or G2～G4 with a p value of 0.419, 0.325, 0.868 respectively, but the prevalence rate of U. urealyticum in G3 was significantly lower than that in other groups. Conclusions M. genitalium is strongly associated with NGU and the prevalence rate is significantly higher in groups with high risk sexual behaviors than that in general population. There is no association between the colonization of U. urealyticum and NGU.

Study on Serotypes of 172 Strains of Ureaplasma urealyticum / 中华皮肤科杂志

0 05), except serotype 3 from NGU patients, which was more commonly found in women than in men (P10%, respectively). Conclusion Serotype 4 was the one most frequently found and strongly related with NGU. It is suggested that the transformation from colonization to pathogenetic status be possible for serotype 3 under the influence of host and a certain environmental condition.

Detection of M.penetrans,M.pirum,M.fermentans and Other Mycoplasmain Patients with Nongonococal Urethritis(Mucopurulentcervicitis) / 中华皮肤科杂志

ObjectiveTodetectM.genitalium(Mg),M.penetrans(Mpe),M.pirum(Mpi),M.fermentans(Mf),Ureaplasmaurealyticum(Uu)andM.hominis(Mh)infectionsinurethra/cervicalcanalandpharynxandexploretheirclinicalsignificance.MethodsCultureandPCRwereperformedin72patientswithNGU/MPCtodetectMg,Mpe,Mpi,Mf,UuandMh.Thesecretionsfromurethra/cervicalcanalandpharynxweretested.ResultsMg,Mpe,Mpi,Mf,UuandMhweredetectedfromgenitalspecimensin23.6%,12.5%,2.8%,0,26.4%and8.5%ofpatients,respectively.Mg,Mpe,Mpi,Mf,UuandMhweredetectedfrompha-ryngealspecimensin24.6%,14.5%,0,0,2.9%and2.9%ofpatients,respectively.Thesamespeciesofmy-coplasmaswerefoundinbothgenitalandpharyngealspecimensin10patients(14.5%).ConclusionsUuandMginfectionsarecommoninpatientswithNGU/MPC.ThenewmycoplasmaspeciesMpeshouldbepaidattentionto.TheresultsindicatethatMgandMpemaybetransmittedbygenital-genitalsexandoral-genitalsex.MfmaybeofnoassociationwithNGU.