Preliminary study on interleukin-1-alpha in squamous cell carcinoma of the head and neck

This study included 25 patients with squamous cell carcinoma of different head and neck regions. Immunohistochemical studies [immunofluorescent and immunoperoxidase] were done for the detection of IL-I alpha at the of the lesion and to correlate its presence with the clinical, histopathological and radiological findings. No relation could be found as regards the age, site ad the presence of 2ry lymph nodes or distant metastasis. Definite synergistic relation was present concerning the undifferen tiation of the malignant cells and the degree of local bone or cartilage erosion. Local tissue destruction should be considered in all cases with high concentration and activity of IL-I alpha before starting the treatment

Evaluation of clinical criteria versus direct microscopic examination and culture in diagnosis of bacterial vaginosis

Thirty two cases completed the study of bacterial vaginosis of which 10 [31.3%] were diagnosed as B.V. depending on the clinical criteria of Amsel et al., [1983 Gram stained smears and culture. The properatin of B.V. among IUD users was statistically significantly higher than that of B.V. among non-IUD users [p< 0.005]. The pH of vaginal secretion [> 4.5] in this study showed 100% sensitivity, 45.5% specificity. However, the presence of clue cells in wet mout examination of vaginal fluid showed 70% sensitivity and 81.8% specificity. The sensitivity and specificity for the detection of fishy odour on addition of 10% KOG and vaginal discharge were 60%, 86.4% and 70% respectively. Compared with clinical criteria for diagnosis of B.V. Gram stained smears were 100% sensitive and 72.2% specific. The isolation of G. Vaginails and Gram stained smears of vaginal fluid were equally sensitive and specific