CORM-2-entrapped ultradeformable liposomes ameliorate acute skin inflammation in an ear edema model

The short release half-life of carbon monoxide (CO) is a major obstacle to the effective therapeutic use of carbon monoxide-releasing molecule-2 (CORM-2). The potential of CORM-2-entrapped ultradeformable liposomes (CORM-2-UDLs) to enhance the release half-life of CO and alleviate skin inflammation was investigated in the present study. CORM-2-UDLs were prepared by using soy phosphatidylcholine to form lipid bilayers and Tween 80 as an edge activator. The deformability of CORM-2-UDLs was measured and compared with that of conventional liposomes by passing formulations through a filter device at a constant pressure. The release profile of CO from CORM-2-UDLs was evaluated by myoglobin assay.

A Case of Pituitary Abscess

Abscess formation within the sellar turcica is a rather entity. The development of such as abscess may be due to a direct extension of adjacent infections, such as sphenoid sinusitis, osteomyelitis of the floor of the sella or infections of other sinuses, or may be transmitted through the blood stream. Several intrinsic lesions of the pituitary gland may favor the development of infections. A case of pituitary abscess is reported in which the clinical history, manifestation and laboratory data of 32 year-old Korean female showed a strong resemblance to those in pituitary adenomas. At operation a soft cystic mass was exposed and identified in the pituitary fossa of which content was yellow pus and drained. Studies of the cyst wall and content demonstrated non-specific inflammation of the pituitary gland. A brief review of abscess in the pituitary fossa is presented.

A Case of Intracranial Malignant Teratoma

A teratoma is a true tumor or neoplasm composed of multiple tissue of kinds foreign to the part in which it arises. Predilection site of intracranial teratoma are the pineal body, the pituitary region and the posterior fossa in order of frequency. We have reported a case of teratoma experienced in a boy aged 12 who disclosed various clinical manifestations of right frontal lobe tumor. The teratoma was malignant histologically and located deeply in the white matter of the right posterior frontal lobe.

Spontaneous Rhinorrhea Induced by Metastatic Carcinoma of the Sphenoid Bone

We have presented a case of spontaneous rhinorrhea which showed recurrence of supparative meningitis and destruction of the sella turhica and sphenoid sinus on the plain skull roentgenograms. By transantral and transnasal route, the portion of sphenoid sinus could easily be approached and exposed. Surgery with microscope easily permitted an identification of the point of cerebrospinal fluid fistula and the repair of it with graft and packing of temporal muscle fascia and pieces of gelfoam. The histopathology of sphenoid bone biopsied was an infiltrating carcinoma.

A Case of Osteolytic Dumb-bell Formed Meningioma

A 37-year-old Korean male was admitted to the hospital in December 1976 because of a slow growing hard mass in the right frontoparietal region near the midline. The patient had noted the mass accidentally while combing his hair six years prior to admission. Since then, the mass had grown slowly but progressively. On admission, there was a hard ovoid mass, 9 by 7 cm in size, over the right frontoparietal region, projecting 3 to 4cm above the normal level of the skull. Skull roentgenogram disclosed a large area of bone destruction and defect, 8 by 6cm, in size at the site of the tumor, accompanying sclerosis along the margin of the bony defect. A tumor located in extracalvarial portion of the head was a well circumscribed one, 9x7x4 cm in size, with no bone tissue over tissue over the tumor. A tumor located in intracranial portion was also a well circumscribed one measuring 5x4x3cm, compressing the brain but not infiltrating. Extracalvarial and intracranial portions of the tumor were interconnected by the pedicle which was a part of the tumor and passed through the defect of the dura mater, 3cm in diameter, nearly in the center of the bony defect. The tumor, dumb-bell formed in extracalvarial and intracranial growths, was completely excised. Pathological diagnosis of the specimen was fibroblastic meningioma.

Two Cases of Brain Tumor Simulating Meningitis

Brain tumors are manifest in a limited variety of ways, presenting with symptoms of increased intracranial pressure and of localized destruction or compression of nervous tissue. Two cases of brain tumor were reported, in which clinical manifestations resembled those of the meningitis, that is, clinical signs and symptoms, as well as cerebrospinal fluid pleocytosis, were consistent with the diagnosis of meningitis.

Two Cases of Brain Tumor Simulating Meningitis

Brain tumors are manifest in a limited variety of ways, presenting with symptoms of increased intracranial pressure and of localized destruction or compression of nervous tissue. Two cases of brain tumor were reported, in which clinical manifestations resembled those of the meningitis, that is, clinical signs and symptoms, as well as cerebrospinal fluid pleocytosis, were consistent with the diagnosis of meningitis.

Experimental Spinal Cord Compression: Part I, Water Content and Oxygen Consumption

Experimental spinal cord compression was successfully produced in the rabbit by the expansion of the stalks of "laminaria", a sea weed, which was placed in the spinal epidural space at the level of fifth lumbar vertebrae. The experimental spinal cord compression and subsequent edema at the site of compression and its adjacent area were studied at interval of 6, 12 and 24 hour's compression by measuring wet weight and dry weight, and by calculating percent water contents, swelling percent and changesa of water content to that in control group. The oxygen consumption of cord tissues at the site of compression and its distal adjacent area of the spinal cord was investigated by using Warburg's manometric apparatus supplying 100% oxygen. In the normal rabbit, the average water content of the spinal cord was 63.38+/-0.9%. The percentage of water and swelling of the cord tissues in experimental group were higher than those in the control during the period of 24 hour's compression, and that at the site of compression they showed a tendency of rapid increase in value at an early stage, and the area adjacent to the compression demonstrated values increasing gradually during the process of compression. In control group, the average value of oxygen consumption of the cord tissue was 0.48+/-0.01---lO2 mg(dry weight)/30 min. The values of oxygen consumption of cord tissue at the site of compression and distal adjacent area were higher than in control group at an early stage and gradually decreased thereafter. It was noted that the changes of water content and oxygen consumption of spinal cord were well and influenced by the mechanical compression with "laminaria" insertion in the rabbit, resulting in spinal cord edema.

Chordoma in the Thoracic Spine: Case Report

Chordomas are congenital tumor which develop from remnant of the notochord. Most of them arise at the clivus Blumenbachii, at the junction of the sphenoidal and occipital bones or sacrococcygeal region. Rarely chordomas arise at the thoracic spine, which compress the spinal cord epidurally and sometimes invade the substance of the spinal cord. The authors report a case of chordoma at T9-T10 vertebral level in which the characteristic "physaliferous" cells were found in the slides of operative specimen. The tumor was compressing the spinal cord and extending into body and lamine of the vertebra, which resulted the patient, 52 year-old Korean male, in paraplegia.

Herniated Upper Lumbar Disc: Case Report

No abstract available.

Experimental Studies in Cerebral Edema: Part 1

The studies of the occurrence and changes of experimental brain edema have been observed by calculating wet weight, volume, dry weight, per cent water content and swelling per cent in 12 normal rabbits as a control group and 24 rabbits of experimental group. The brain edema was induced by expansion of laminaria which resulted in brain compression, that was inserted into the supratentorial extradural space of rabbit. The piece of section of laminaria which is a sea weed and used for the purpose of slow expanding space-occupyin gmass has a characteristic mode of slow expansion in volume on contact with water. The average wet weight of cerebral hemisphere of normal rabbits was 3.30+/-0.19 gm. The average dry weight of unilateral hemisphere of 156 from 78 rabbits was 0.69+/-0.04 gm, while its volume was 2.97+/-0.29 ml and the percentages of water content was 78.92+/-1.36 per cent. The weight, volume and percentages of water content and swelling in the compressed sides of hemisphere showed higher values compared them to the opposite noncompressed hemisphere in the "laminaria-compression" group and showed gradually increasing tendency in the values as the time elapsed.