Benefit and limitation of multi detector computed tomography in local staging of endometrial carcinoma

Objective: To evaluate the role of multidetector computed tomography MDCT in the local staging of endometrial carcinoma

Patients and Methods: Twenty five women with endometrial carcinoma were prospectively examined with MDCT scanning of abdomen and pelvis after intravenous administration of iodinated contrast media and the results were correlated with that of histopathology

Result: MDCT had a good accuracy in local staging of endometrial carcinoma in relation to myometrial infiltration and cervical invasion

Conclusion: While MDCT is an accurate tool for local staging of endometrial carcinoma and it determines whether the case is operable or not, yet MRI with high soft tissue resolution should be preserved for selected cases

Anti-mullerian hormone, inhibin B and antral follicle count as markers of premature ovarian failure in women with type I diabetes mellitus

To evaluate the different markers of ovarian reserve [AMH-Inhibin B, FSH and antral follicle count [AFC] in insulin dependent diabetes mellitus [IDDM]. We studied 30 patients with IDDM as study groups [10cases >/=32 years group IV and 20 cases 32 years group III and 12 cases <32 years group I. Serum levels of FSH, LH, inhibin B and AMH were measured at [days 1-7] of menstrual cycle and AFC was done by trans vaginal ultrasound. AMH levels were lower in IDDM patients than in controls > 32 years [2.35 +/- 2.2 versus 7.79 +/- 1.73 p<0.000]. Also IDDM groups showed lower levels of inhibin B. While there is no difference in the levels of FSH. AFC is valuable for the diagnoses of premature ovarian failure in IDDM. Compared with FSH [AMH and inhibin B] are more valuable for the diagnosis of premature ovarian aging in IDDM patients which developed earlier decline in the ovarian follicle pool compared with the healthy women and also AMH is more valuable than AFC for detection of premature ovarian failure in IDDM