RESUMO
Vitamin D in complex with its receptor by regulating gene expression, endometrium immune response and stimulation of endometrium decidualization can be involved in implantation. So, it seems that the amount of vitamin D in follicular fluids [FF] may have an association with ART success. First, we intended to investigate the possible association between levels of follicular fluids 25-OH vitamin D with assisted reproductive outcomes. Second, we examined relationship between 25-OH vitamin D levels with number and quality of oocytes. In a prospective study, 80 infertile female candidates for IVF/ICSI were enrolled. Blood samples [on the day of human chorionic gonadotropin administration] and follicular fluids were taken, and then levels of serum estradiol and follicular fluids 25-OH vitamin D were measured. Also clinical characteristics of patients [duration of infertility, causes of infertility, menstrual status], number and quality of oocytes, number of fertilized oocytes, estradiol levels, and clinical pregnancy were evaluated. Concentration of FF 25-OH vitamin D in pregnant women was significantly higher than non-pregnant women [p=0.007] but there were no significant differences in age, body mass index [BMI], duration of infertility, menstrual status, number of oocytes, oocytes quality, number of fertilized oocytes, and serum estradiol levels between the two groups. Statistically positive correlation was found between 25-OH vitamin D levels with patient age and implantation rate [r=0.264, p=0.018 and r=0.301, p-0.007 respectively]. The obtained results suggest that vitamin D without affecting the number and quality of oocytes can independently improve implantation rate and 1VF outcome