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Artigo em Chinês | WPRIM | ID: wpr-349058

RESUMO

<p><b>OBJECTIVE</b>To establish a multicolor primed in situ labeling (PRINS) protocol for chromosome detection in uncultured amniocytes.</p><p><b>METHODS</b>Chromosomes 18, X and Y in uncultured amniocytes were simultaneously detected by using the non-ddNTP-blocking multicolor PRINS procedure.</p><p><b>RESULTS</b>Within 7 h, the 3 chromosomes were simultaneously marked in the same uncultured amniocyte. The chromosome signals were successfully detected in 69 uncultured samples of amniotic fluid. The results were consistent with that obtained by chromosomes in cultured amniocytes.</p><p><b>CONCLUSION</b>This multicolor protocol was high throughput, fast, simple, sensitive and reliable in diagnosing chromosome abnormalities in uncultured amniocytes.</p>


Assuntos
Adolescente , Adulto , Feminino , Humanos , Gravidez , Adulto Jovem , Líquido Amniótico , Química , Biologia Celular , Células Cultivadas , Cromossomos Humanos Par 18 , Química , Genética , Cromossomos Humanos X , Química , Genética , Cromossomos Humanos Y , Química , Genética , Hibridização in Situ Fluorescente , Métodos , Diagnóstico Pré-Natal , Métodos , Marcação in Situ com Primers , Métodos
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