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Objective:To analyze the effect of hospital-community-family health management on self-efficacy and quality of life (QoL) assessments in discharged patients with nephrotic syndrome (NS).Methods:A total of 102 NS patients who received treatment at the Department of Nephrology in the Affiliated Hospital of Southwest Medical University from January 2018 -January 2019 were selected, and randomized to intervention or control group. The intervention and control group implemented hospital-community-family health management and routine health management for 6 months, respectively. In addition to serum biochemistry and routine urine tests, the general self-efficacy scale (GSES) and QoL (by short form-36 questionnaire; SF-36) assessments were performed in both groups and compared.Results:The levels of 24-hour urine protein, serum creatinine (Scr), blood urea nitrogen (BUN) and plasma albumin, and the GSES and SF-36 assessments were comparable between groups at baseline ( P>0.05). Levels of 24-hour urine protein, Scr and BUN were found to be significantly lower ( P<0.05) in the intervention group than the control group (1.50±0.42 vs. 1.90±0.61 g/L, 152.35±20.31 vs. 185.36±15.59 μmol/L, 7.89±2.01 vs. 10.32±2.35 mmol/L, respectively); however, the intervention group showed a significant increase ( P<0.05) in plasma albumin levels as compared to the control group (32.35±4.48 vs. 29.85±4.35). The intervention group reported significantly higher ( P<0.001) GSES score than the control group (3.00±0.56 vs. 2.45±0.45 points), indicating a better ability of patients in the intervention group to cope up with the daily routine activities. The post-intervention scores of the individual domains, namely overall health, physiological function, physical pain, energy, and mental health, in the SF-36 questionnaire were significantly higher ( P<0.001) in the intervention group than the control group (57.01±4.31 vs. 53.10±4.60 points, 70.06±5.61 vs. 64.02±5.50 points, 65.01±4.31 vs. 61.01±4.80 points, 65.41±5.40 vs. 60.42±5.12 points, 74.40±6.80 vs. 65.42±7.12 points, respectively), implying a better health status in the intervention group. Conclusions:The implementation of hospital-community-family health management during the post-discharge home recuperation period of NS patients can improve their biochemical parameters and QoL, and boost their confidence in the performance of daily routine activities.
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OBJECTIVE:To observe clinical efficacy and safety of Danning tablets combined with endoscopic ligation in the treatment of esophageal varices in patients with nonalcoholic fatty liver cirrhosis(NFLC). METHODS:A total of 70 NFLC patients with esophageal varices in our hospital during Sept. 2015-Sept. 2016 were divided into control group and observation group by simple random sampling method,with 35 cases in each group. Both groups received endoscopic ligation. Control group was given Somatostatin for injection with intravenous pump at the speed of 250 μg/h for 72 h after surgery,and Pantoprazole sodium enteric-coated capsules 40 mg,qd. Observation group was additionally given Danning tablets 1 g,tid,on the basis of control group. Both groups were given medicine for consecutive 4 weeks.The situation of ligation and clinical efficacies were observed in 2 groups,and the grading of esophageal varices before and after treatment,the occurrence of re-bleeding events and ADR were observed. RESULTS:The patients of 2 groups completed ligation successfully,there was no statistical significance in the times of ligation between 2 groups(P>0.05). Total response rate of observation group was 91.43%,which was significantly higher than 74.29% of control group,with statistical significance(P<0.05).Before treatment,there was no statistical significance in the grading of esophageal varices between 2 groups(P>0.05). One month and three months after treatment,the grading of esophageal varices in 2 groups were significantly better than before treatment,and observation group was significantly better than control group,with statistical significance(P<0.05). There was no statistical significance of 2 groups between 3 months after treatment and one month after treatment(P>0.05).Total incidence of re-bleeding events in observation group was 14.29% within 3-month follow-up,which was significantly lower than 40.00% of control group,with statistical significance(P<0.05). There was no statistical significance in the total incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Danning tablets combined with endoscopic ligation show significant therapeutic efficacy for esophageal varices of NFLC,significantly mitigate the degree of esophageal varices and reduce the incidence of re-bleeding without increasing the occurrence of ADR.
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To study the effect of compressible limb sleeve system on tumefaction of limbs and recurrence of thrombus in patients underwent venous thrombectomy of deep venous thrombosis (DVT). Sixty-two patients underwent venous thrombectomy of DVT between September 2004 and July 2005 were selected from Affiliated Hospital of Luzhou Medical College, and then were randomly divided into the experimental group and the control group. Patients in the control group were given usual care after the surgery, while patients in the experimental group were treated by compressible limb sleeve system based on usual care (once a day and 30 minutes each time. 14 days were taken as one course, and there were totally 2 courses). The circumference, recurrence rate of thrombus and warmth sensation of affected limb were observed before and after the treatment in both groups. Detection at 28 days after the treatment showed that the circumference of patients in the experimental group decreased, and the score of warmth sensation decreased. There were significant differences in comparison with those in the control group before the treatment (P