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Objective:To evaluate the clinical efficacy of Wanfu-Qutong Decoction combined with esomeprazole in the treatment of chronic atrophic gastritis (CAG). Methods:A total of 106 CAG patients who met the inclusion criteria from June 2017 to June 2019 were randomly divided into two groups with 53 in each group. The control group took esomeprazole magnesium enteric coated tablets, and the observation group took Wanfu-Qutong Decoction on the basis of the control group. Both groups were treated continuously for 3 months. TCM syndrome score was performed before and after treatment, and the new Sydney system intuitive simulation score method was used to score the histopathology of gastric mucosa. The levels of gastrin 17 (G-17), pepsinogen (PGⅠ , PGⅡ) and the PG Ⅰ/Ⅱ were measured by ELISA. Results:The total effective rate was 96.2% (51/53) in the observation group and 79.2% (42/53) in the control group. There was significant difference between the two groups ( χ2=7.414, P<0.01). After treatment, the scores of epigastric pain, fullness, liking temperature and pressing, vomiting clear water, eating less and staying foolish, and limb burnout in the observation group were significantly lower than those in the control group ( t values were 2.788, 3.632, 3.816, 1.590, 2.183, 2.103, respectively, all Ps<0.05), and the scores of chronic inflammatory reaction, inflammatory activity, atrophy degree, dysplasia and intestinal metaplasia in the mucosa were significantly lower than those in the control group ( t values were 2.983, 2.106, 2.106, 3.773, 1.922, 3.095, respectively, all Ps<0.05). After treatment, the serum G-17 [(14.47 ± 3.06) pmol/L vs. (10.67 ± 2.47) pmol/L, t=10.510] and PG Ⅰ [(130.31 ± 14.79) μg/L vs. (102.36 ± 12.63) μg/L, t=8.178] and PG Ⅰ/Ⅱ [(10.45 ± 0.48) vs. (9.17 ± 0.72), t=2.104] in the observation group were significantly higher than those in the control group ( P<0.01 or P<0.05). Conclusion:Wanfu-Qutong Decoction combined with esomeprazole tablets can effectively improve the clinical symptoms of CAG patients, regulate the levels of G-17, PG Ⅰ , PG Ⅱ and PGⅠ/Ⅱ, and promote the repair of gastric mucosa.
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Objective:To evaluate the clinical efficacy of modified Baihe-Gujin Decoction combined with routine chemotherapy for the elderly patients with primary treated pulmonary tuberculosis and lung-kidney yin deficiency. Methods:A total of 94 patients who met the inclusion criteria in our hospital from January 2016 to January 2018 were selected and divided into 2 groups according to the random number table method, with 47 patients in each group. The control group was treated with the routine chemotherapy regimen of 2HRZE/4HR (H: isoniazid, R: rifampicin, Z: pyrazinamide, E: ethambutanol), the observation group was treated with Baihe-Gujin Decoction on the basis of the routine chemotherapy. Both groups were treated continuously for 6 months. The sputum negative rate was observed 2, 5 and 6 months after treatment, The closure of cavity shadows was observed by chest CT. The content of IL-6 and IFN-γ-inducible protein-10 were detected by double antibody sandwich ELISA. T cell subsets was detected by flow cytometry. And the clinical efficacy was evaluated. Results:The total effective rate was 87.2% (41/47) in the observation group and 61.7% (29/47) in the control group, and the difference between the two groups was statistically significant ( χ2=8.050, P=0.004). After treatment, the TCM syndrome score of the observation group was significantly lower than that of the control group ( t=5.698, P<0.01). At the end of 6 months after treatment, the sputum negative rate in the observation group was significantly higher than that of the control group ( t=5.317, P=0.021), the effective rate of cavity shadow closure (95.7% with 45/47 vs. 83.0% with 39/47) in the observation group was significantly higher than that of the control group ( χ2=4.029, P=0.044). After treatment, the levels of CD3 +, CD4 + and CD4 +/CD8 + in the observation group were all significantly higher than those in the control group ( t values were 2.107, 3.571 and 2.351, respectively, all Ps<0.05), and the levels of CD8 + in the observation group were all significantly lower than those in the control group ( t=2.711, P=0.005). The levels of IL-6 and IFN-γ-induced protein-10 in the observation group were significantly lower than those in the control group ( t values were 2.517 and 2.890, respectively, all Ps<0.05). Conclusions:The modified Baihe-Gujin Decoction combined with routine chemotherapy can improve the immunity of the elderly patients with primary treated pulmonary tuberculosis with lung-kidney yin deficiency, and improve the clinical efficacy.
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Objective To establish a rapid and efficient method for the simultaneous determination of ginsenoside Rg1 and ginsenoside Re in Tongru granules by HPLC.Methods The HPLC analysis was carried out with Agilent ZORBAX SB-C18 and acetonitrile-0.1％ phosphoric acid(15:85,V/V) as mobile phase,the flow rate was 1.0 ml/min,the column temperature was 30 ℃,injection volume was 10 μl,and the detection wavelength was 203 nm.Results The Rg1 solution of ginsenoside showed a good linear relation between 0.136-2.040 μg (r2=0.999 9).The ginsenoside Re solution presented a good linear relationship (r2=0.999 8)between 0.066-0.990 μg,with the average addition recovery of 99.3％ and 99.1％,and the relative standard deviation of 0.84％ and 0.75％(n=6),respectively.Conclusions The method is highly specific,sensitive,reproducible,simple and efficient which can be used for quality control of Tongru Granules.