CXCL4 and its receptor in colorectal cancer / 国际肿瘤学杂志

CXC chemokine ligand 4 (CXCL4) is a platelet-derived chemokine,and it belongs to CXC subfamily.Its receptor is CXC chemokine receptor 3 (CXCR3),which belongs to the seven transmebrane G-protein-coupled receptor family,and its coreceptor is glycosaminoglycan (GAG).CXCL4 and its receptors take part in the regulation of many biological processes,such as immune regulation,inflammatory response,endothelial cell proliferation and migration and angiogenesis.Recent studies show that CXCL4 and its receptor have significant influence on the cell growth,angiogenesis,invasion and metastasis of colorectal cancer,which offers a new perspective to explore the mechanism of colorectal cancer and its targeted therapy.