Nurse-led translational research: An emerging field in multidisciplinary research

Translational research is well-known concept in healthcare still nurse-led translational research is an emerging area of multidisciplinary nursing research. This study intends to offer an in-depth look at translational research and the process for its applications in nursing education, practice, and research. Nurses, educators, researchers, and policymakers will better understand nurse scientists’ expanded role in education and clinical practice. This paper will assist the nurse educators, researchers to stay informed of translational research and its nursing impact. To develop a narrative synthesis study, a detailed systematic literature review was conducted in Pub Med, Web of Sciences, Scopus, ProQuest, Ovid using the keywords “translational research,” “nursing,” “implementation science,” “barriers in translational research” themes generated in selected paper are discussed in detail in this paper. 32 articles were found to be relevant to discuss the concepts of translational research in nursing practices. In contrast to basic research, translational research works cooperatively to assess the efficacy of evidence from the bench to the bed, from one realm to another. It requires the transparent method for dealing with roadblocks, such as following evidence-based recommendations while assessing evidence, so that policymakers can determine whether to embrace them for the development of the health-care system. Nurse-led translational research under the direction of a nurse scientist has the potential to advance nursing excellence in both clinical and community health settings.

Chromium (VI) biosorption by immobilized Aspergillus niger in continuous flow system with special reference to FTIR analysis.

Aspergillus niger was treated with acid and immobilized in calcium alginate matrix. The dynamic removal of Cr (VI) ion was studied using continuously fed column packed with immobilized biosorbent beads. Column experiments were carried out to study the effect of various bed heights (20, 30, 40 cm) under different flow rates (5, 7.5, 10 ml min-1) on efficiency of biosorption. The maximum time (1020 minutes; 17 hr) before breakthrough point was observed in case of 40 cm bed height with flow rate of 5ml min-1. FTIR analysis of acid treated immobilized A.niger was used for a qualitative and preliminary analysis of chemical functional groups present on its cell wall which provided the information on nature of cell wall and Cr (VI) interaction during the process of biosorption. The IR spectra of biosorbent recorded before and after chromium biosorption had shown some changes in the band patterns, which were finally analyzed and was found that chemical interaction such as ion-exchange between carboxyl (-COOH), hydroxyl (-OH) and amine (-NH2) group of biosorbent and Chromium ion were mainly involved in biosorption of Cr (VI) onto A. niger cell wall surface. The biosorbed metal was eluted from biosorbent by using 0.1 M H2SO4 as eluant. Immobilized biosorbent could be reused for, five consecutive biosorption and desorption cycles without apparent loss of efficiency after its reconditioning. Considering all above factors together this paper discusses the efficient chromium biosorption process carried out by immobilized A. niger biosorbent.

Renal thrombotic microangiopathy and cerebral venous thrombosis in a young man.

We report a patient of primary catastrophic antiphospholipid syndrome who presented with rapidly progressive renal failure and seizures. He was detected to have thrombotic microangiopathy on kidney biopsy and deep cerebral venous thrombosis. The patient was successfully managed with anticoagulants, steroids, plasmapheresis and cyclophosphamide.

Ethnomedicine: use in dental caries

Ubiquitousness and increasing prevalence of dental caries makes it one of the most important problems in public health. Due to high cost and lack of resources at primary levels prevention is better in dental caries. Since the origin is related to bacteria, antibacterial is mainstay of treatment. Lack of high efficacy with antibacterial agents, unwanted effects and resistance to these agents are drawing attention of scientists to search for new and better drugs. Plants products are currently gaining attention for treatment of various ailments. Although, these has been exploited for various oral ailments this article describes use of plants products for prevention and cure of dental caries.

Hepatitis C virus-related fibrosing cholestatic hepatitis in a renal transplant recipient.

Fibrosing cholestatic hepatitis (FCH) is a severe and progressive form of liver dysfunction seen in organ transplant recipients and immunosuppressed patients; it is usually associated with hepatitis B virus infection. We report 36-year-old man, a renal transplant recipient, also developed FCH with hepatitis C virus infection and succumbed to it.

Impact of hepatitis C virus infection in renal transplant recipients.

OBJECTIVES: The impact of hepatitis C virus (HCV) infection on the success of renal transplant is controversial. We assessed the effect of HCV infection on graft and patient survival in renal allograft recipients. METHODS : We retrospectively analyzed medical records of renal allograft recipients who were transplanted between June 1990 and March 2004. Patients were divided into those positive and negative for anti-HCV antibody. Graft and patient survival were compared between the groups. RESULTS : Of 126 patients studied (median age 34.5 years, range, 16-60; 111 men), 35 were positive for anti-HCV antibody. In seven patients, the antibodies were detected for the first time after renal transplant. Mean patient and graft survival duration in the anti-HCV negative group was longer (55 [SD 2] months [95% CI, 51-58]) than in the anti-HCV positive group (50 [SD 4] months [95% CI, 43-58]) (p< 0.05). Twenty-two patients died - 8 (22.8%) in the anti-HCV positive group and 14 (15.3%) in the negative group. In the anti-HCV positive group, infections were the cause of death in 5 patients and 3 patients died of liver cell failure. In the anti-HCV negative group, corresponding figures were 13 and one. CONCLUSION: HCV infection is a bad prognostic indicator for patient and graft survival duration in renal transplant recipients. Infections are the commonest cause of death in renal transplant recipients.